Translational Neuroendocrinology

Faculty of Medicine | Lund University


Rana Soylu


rana soylu

Rana Soylu,  Post doc
Born on May 27th 1982 in Turkey
Phone: +46 46 222 45 57


 Translational Neuroendocrinology Research Unit
 Lund University, BMC D11
 SE-221 84 Lund, Sweden




Postdoctoral fellowship, TNU, Medical Faculty, Lund University, Sweden


PhD studies in Neuroscience, Medical Faculty, Lund University, Sweden
Supervisor: Associate Professor Åsa Petersén.
Project: Molecular mechanisms of hypothalamic changes in Huntington’s disease.  


Course in Human Biology, preparatory course for postgraduate studies, Medical Faculty, Lund University, Sweden
Project: Neuropathological analysis after delivery of adeno- associated viral vectors expressing huntingtin fragments or cre-recombinase in the hypothalamus of mice.  


Masters Degree, Hacettepe University Institiute of Health Sciences, Medical Biology MSc Program, Ankara, Turkey
Supervisor: Associate Professor Cetin Kocaefe
Thesis: Characterization of muscle precursor cells on the course of chronic muscle degeneration. 


Bachelor Degree, Hacettepe University Faculty of Science, Department of Biology, Ankara, Turkey



Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease.
Neuropathology and Applied Neurobiology. 2018 Jul 18. doi: 10.1111/nan.12514. [Epub ahead of print]

Soylu-Kucharz R, Baldo B and Petersén Å.
Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.
Scientific Reports 6: 28322 (2016)

Soylu-Kucharz R, Adlesic N, Baldo B, Kirik D and Petersén Å.
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
Sci Rep. Sep 30;5:14598 (2015)

Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller H, Rasche V, Ferger B, Dirrig-Grosch S, Soylu-Kucharz R, Petersén A, Walther P, Linkus B, Kassubek J, Wong PC, Ludolph AC and Dupuis L.
Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein mediated neurodegeneration.
Human Molecular Genetics 24(8): 2228-2240 (2015)

Baldo B, Soylu R and Petersén Å.
Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction.
PLOS ONE 8 (12) e83050 (2013)

Hult Lundh S, Nilsson N, Soylu R, Kirik D and Petersén Å.
Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease.
Human Molecular Genetics 22: 3485-3497 (2013)

Lundh SH, Soylu R and Petersén Å.
Expression of Mutant Huntingtin in Leptin Receptor-Expressing Neurons Does Not Control the Metabolic and Psychiatric Phenotype of the BACHD Mouse.
PLoS ONE 7(12): e51168 (2012)

Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D and Petersén Å.
Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
European Journal of Neuroscience 36(6):2789-800 (2012)

Soylu R*, Hult S*, Björklund T, Belgardt BF, Mauer J, Brüning JC, Kirik D and Petersén Å.
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
Cell Metabolism 13: 428-439 (2011) *equal contribution

Mikrouli E, Wörtwein G, Soylu R, Mathé AA and Petersén Å.
 Increased numbers of orexin/hypocretin neurons in a genetic rat depression model.
 Neuropeptides 45(6): 401-406 (2011)

Braunstein KE, Eschbach J, Ròna-Vörös K, Soylu R, Mikrouli E, Larmet Y, Rene F, Gonzalez de Aguilar JL, Loeffler JP, Müller HP, Bucher S, Kaulisch T, Niessen HG, Tillmanns J, Fischer K, Schwalenstocker B, Kassubek J, Pichler B, Stiller D, Petersen Å, Ludolph AC and Dupuis L.
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.  
Human Molecular Genetics 19: 4385-98 (2010)

Hult S, Schultz K, Soylu R and Petersén Å.
Hypothalamic and Neuroendocrine Changes in Huntington's Disease.  
Current Drug Targets 11: 1237-1249 (2010)

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