Translational Neuroendocrinology

Faculty of Medicine | Lund University

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Rachel Cheong

rachel cheong

Rachel Cheong,  Post doc 
Born on December 3rd 1986
Phone: +46 46 222 17 27
E-mail: Rachel.Cheong@med.lu.se

Translational Neuroendocrinology Research Unit
Lund University, BMC D11
SE-221 84 Lund, Sweden

Education

Feb 2013 - ongoing

Postdoctoral fellowship, TNU, Medical Faculty, Lund University, Sweden
Project: Role of hypothalamic dysfunction for non-motor aspects of Huntington's disease.
Supervisor: Associate Professor Åsa Petersen

2009 - 2012

Doctor of Philosophy: Neurobiology
University of Otago, New Zealand
Thesis: Effects of estradiol on gonadotropin-releasing hormone neurons
Supervisor: Dr. István Abrahám and Professor Allan Herbison

2008

Bachelor of Biomedical Science with Honours (First Class Honours)
University of Otago, New Zealand
Dissertation title: Estrogen induces rapid ERK1/2 phosphorylation in GnRH neurons in vivo.

2005 - 2007

Bachelor of Biomedical Science in Human Reproduction and Development
University of Otago, New Zealand

Publications

Fjalldal S, Follin C, Gabery S, Sundgren PC, Björkman-Burtscher IM, Lätt J, Mannfolk P, Nordström CH, Rylander L, Ekman B, Cheong R, Pålsson A, Petersén Å and Erfurth EM.
Detailed assessment of hypothalamic damage in craniopharyngioma patients with obesity.
International Journal of Obesity. 2018 Sep 4. Doi: 10.1038/s41366-018-0185-z. [Epub ahead of print]

Baldo B, Sajjad MU, Cheong RY, Bigarreau J, Vijayvargia R, McLean C, Perrier AL, Seong IS, Halliday G, Petersén Å and Kirik D.
Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay.
ENeuro 5 (4): ENEURO.0234-18.2018 (2018)

Siebzehnrübl FA, Raber KA, Urbach YK, Schulze-Krebs A, Canneva F, Moceri S, Habermeyer J, Achoui D, Gupta B, Steindler DA, Stephan M, Nguyen HP, Bonin M, Riess O, Bauer A, Aigner L, Couillard-Despres S, Paucar MA, Svenningsson P, Osmand A, Andreew A, Zabel C, Weiss A, Kuhn R, Moussaoui S, Blockx I, Van der Linden A, Cheong RY, Roybon L, Petersén Å and von Hörsten S.
 Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.
 PNAS 115 (37): E8765-E8774 (2018)

Gawlik KI, Harandi VM, Cheong RY, Petersén Å and Durbeej M.
 Laminin α1 reduces muscular dystrophy in dy2J mice.
 Matrix Biology 70: 36-79 (2018)

Gabery S, Georgiou-Karistianis N, Lundh SH, Cheong RY, Churchyard A, Chua P, Stout JC, Egan GF, Kirik D and Petersén Å.
Volumetric Analysis of the Hypothalamus in Huntington Disease Using 3T MRI: The IMAGE-HD Study.
PLoS One. 2015 Feb 6;10(2):e0117593.

Baldo B, Cheong RY and Petersén Å.
Effects of Deletion of Mutant Huntingtin in Steroidogenic Factor 1 Neurons on the Psychiatric and Metabolic Phenotype in the BACHD Mouse Model of Huntington Disease.
PLoS One 9(10): e107691 (2014)

Cheong RY, Czieselsky K, Porteous R, Herbison AE.
Expression of ESR1 in Glutamatergic and GABAergic Neurons Is Essential for Normal Puberty Onset, Estrogen Feedback, and Fertility in Female Mice.
Journal of Neuroscience (2015) 35(43):14533-43.

Cheong RY, Porteous R, Chambon P, Abrahám I, Herbison AE.
Effects of neuron-specific estrogen receptor (ER) α and ERβ deletion on the acute estrogen negative feedback mechanism in adult female mice.
Endocrinology (2014) 155(4):1418-1427.

Kwakowsky A, Cheong RY, Herbison AE, Ábrahám IM.
Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: mechanisms and role.
Frontiers in Neuroendocrinology (2014) 35(1):31-41.

Kwakowsky A, Koszegi Z, Cheong RY, Abrahám IM.
Neuroprotective effects of non-classical estrogen-like signaling activators: from mechanism to potential implications.
CNS Neurol Disord Drug Targets (2013) 12(8):1219-25.

Cheong RY, Kwakowsky A, Barad Z, Porteous R, Herbison AE and Ábrahám IM.
Estradiol acts directly and indirectly on multiple signaling pathways to phosphorylate cAMP-response element binding protein in gonadotropin-releasing hormone neurons.
Endocrinology (2012) 153: 3792-3803.

Kőszegi Z, Szegő EM, Cheong RY, Tolod-Kemp E and Ábrahám IM.
Post-lesion estradiol treatment restores cortical cholinergic innervations via estrogen receptor alpha dependent non-classical estrogen signaling in vivo.
Endocrinology (2011) 152: 3471-82.

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