Stem Cell Center

Faculty of Medicine | Lund University

Congratulations to the Pereira group on their publication in Science Immunology

2018-12-17

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L-R: Fábio Rosa (PhD student), Cristiana Pires (Postdoc), Filipe Pereira (PI) & Gabriela Ferreira (PhD student)

Congratulations to Fábio Rosa, Cristiana Pires, Gabriela Ferreira and Filipe Pereira at the Pereira lab @CellReproLab on the publication of the work "Direct reprogramming of fibroblasts into antigen-presenting dendritic cells" in Science Immunology, featured on the cover and accompanied by a nice commentary.

Taking a leaf from the regenerative medicine handbook into immunology, Rosa et al. found that ectopic expression of transcription factors PU.1, IRF8, and BATF3 reprogrammed mouse and human fibroblasts to “induced” dendritic cells (iDCs). Human and murine iDCs were comparable to conventional type 1 DCs and had the ability to engulf and present antigens; murine iDCs could also cross-present antigens to CD8+ T cells. This system may be useful in the clinic for generation of patient-specific DCs, and opens up the possibility of generating other DC subsets by reprogramming. Congratulations to the authors!

Read the press release from Lund University

https://www.med.lu.se/nyheter/181210_pereira

The paper “Direct reprogramming of fibroblasts into antigen-presenting dendritic cells” and the commentary “Good things come in threes” can be downloaded here:

http://immunology.sciencemag.org/content/3/30/eaau4292

http://immunology.sciencemag.org/content/3/30/eaav5545

p1500589
L-R: Fábio Rosa (PhD student), Cristiana Pires (Postdoc), Filipe Pereira (PI) & Gabriela Ferreira (PhD student)

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