Congratulations to Fábio Rosa, Cristiana Pires, Gabriela Ferreira and Filipe Pereira at the Pereira lab @CellReproLab on the publication of the work "Direct reprogramming of fibroblasts into antigen-presenting dendritic cells" in Science Immunology, featured on the cover and accompanied by a nice commentary.
Taking a leaf from the regenerative medicine handbook into immunology, Rosa et al. found that ectopic expression of transcription factors PU.1, IRF8, and BATF3 reprogrammed mouse and human fibroblasts to “induced” dendritic cells (iDCs). Human and murine iDCs were comparable to conventional type 1 DCs and had the ability to engulf and present antigens; murine iDCs could also cross-present antigens to CD8+ T cells. This system may be useful in the clinic for generation of patient-specific DCs, and opens up the possibility of generating other DC subsets by reprogramming. Congratulations to the authors!
Read the press release from Lund University
The paper “Direct reprogramming of fibroblasts into antigen-presenting dendritic cells” and the commentary “Good things come in threes” can be downloaded here: