Lund Stem Cell Center
Funded by StemTherapy, one of six strategic research areas of excellence in life sciences at Lund University, (supported by the Swedish Foundation for Strategic Research and the Swedish Government), the Stem Cell Center (SCC) was established in January 2003. Lund SCC center focuses on stem cell and developmental biology of the central nervous and blood systems, and development of stem cell and cell replacement therapies in these organ systems as well as research in non-mammalian model systems.
Congratulations to Fábio Rosa, Cristiana Pires, Gabriela Ferreira and Filipe Pereira at the Pereira lab @CellReproLab on the publication of the work "Direct reprogramming of fibroblasts into antigen-presenting dendritic cells" in Science Immunology, featured on the cover and accompanied by a nice commentary.
Taking a leaf from the regenerative medicine handbook into immunology, Rosa et al. found that ectopic expression of transcription factors PU.1, IRF8, and BATF3 reprogrammed mouse and human fibroblasts to “induced” dendritic cells (iDCs). Human and murine iDCs were comparable to conventional type 1 DCs and had the ability to engulf and present antigens; murine iDCs could also cross-present antigens to CD8+ T cells. This system may be useful in the clinic for generation of patient-specific DCs, and opens up the possibility of generating other DC subsets by reprogramming. Congratulations to the authors!
Congratulations to the Pereira lab @CellReproLab on the publication of the work "Cooperative transcription factor induction mediates hemogenic reprogramming" in Cell Reports.
In this study, Gomes et al. show that specification of hemogenesis in human fibroblasts is mediated by cooperative transcription factor binding. GATA2 displays dominance, interacts with GFI1B and recruits FOS to open chromatin simultaneously silencing the fibroblast program and initiating an endothelial to hematopoietic transition to definitive hematopoiesis. This is the first time that the mechanism of blood stem cell reprogramming is described and provides a platform for the future development of patient-specific hematopoietic progenitors from human dermal fibroblasts.
- Read the press release from Lund University
- The paper “Cooperative transcription factor induction mediates hemogenic reprogramming” can be downloaded here:
Congratulations Isaac Canals and Henrik Ahlenius on the publication of your work "Rapid and efficient induction of functional astrocytes from human pluripotent stem cells" in Nature Methods.
In this study, the authors show that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. In our study these cells exhibited molecular and functional properties resembling those of adult human astrocytes and were deemed suitable for disease modeling. Our method provides new possibilities for the study of human astrocytes in health and disease.
Congratulations to all authors!
On September 21, 2018, Dimitra Zacharaki, Division of Molecular Hematology, successfully defended her thesis entitled "Human Bone Marrow Mesenchymal Stromal Stem Cells in Health and Disease".
Faculty opponent was Professor Dominique Bonnet of the Francis Crick Institute, London, UK. Main supervisor for Dimitra's PhD studies was Professor Stefan Scheding.
On September 13, 2018, Roman Galeev, Division of Molecular Medicine and Gene Therapy, successfully defended his thesis entitled "Identification of intrinsic regulators in normal and malignant human hematopoiesis - An RNA-interference approach".
Faculty opponent was Professor Johannes Zuber, Medical University of Vienna, Austria. Main supervisor for Roman's PhD studies was Professor Jonas Larsson.