Lund Stem Cell Center
Funded by StemTherapy, one of six strategic research areas of excellence in life sciences at Lund University, (supported by the Swedish Foundation for Strategic Research and the Swedish Government), the Stem Cell Center (SCC) was established in January 2003. Lund SCC center focuses on stem cell and developmental biology of the central nervous and blood systems, and development of stem cell and cell replacement therapies in these organ systems as well as research in non-mammalian model systems.
Dissertation Roman Galeev
Division of Molecular Medicine & Gene Therapy, Department of Laboratory Medicine
Title: "Identification of intrinsic regulators in normal and malignant human hematopoiesis - An RNA-interference approach"
Date: September 13, 2018 at 9 am
Place: Lux Aula övre, LUX
Opponent: Professor Johannes Zuber, Medical University of Vienna, Austria
Main supervisor: Professor Jonas Larsson
Congratulations to Stem Cell Center PI Darcy Wagner on her recent publication “Co-opting of ClinicalTrials.gov by patient-funded studies” in Lancet Respiratory Medicine. The article addresses the problem of for-profit companies using clinicaltrials.gov to legitimize experimental cell-based therapies for respiratory diseases - a growing problem also in terms of stem cell trials.
Congratulations to Stem Cell Center PI Darcy Wagner on receiving an ERC starting grant. The award is for her research on ”Bioengineering lung tissue using extracellular matrix based 3D bioprinting”.
The aim of Darcy's proposal is to use custom 3D bioprinters to generate contructs mimicking lung tissue using an innovative approach combining primary cells, the engineering reproducibility of synthetic materials, and the biologically constructive properties of acecellular lung (hybrid). "The concept is to 3D bioprint hybrid murine and human lung tissue models and test gas exchange, angiogenesis and in vivo immune responses. This project will be a critical first step in demonstrating feasibility of 3D bioprinting lung tissue in order to create new options to increase available tissue for lung transplantation."
Congratulations Francesca Romana Stefani and Johan Bengzon (Department of Clinical Sciences, Division of Neurosurgery) on the publication of your work "Low-dose irradiated mesenchymal stromal cells break tumor defensive properties in vivo" in the International Journal of Cancer.
In this study, the authors uncover a novel indirect role for cellular therapy in cancer and propose a new effective tool for manipulating mesenchymal stromal cell (MSC) immune phenotype, which in turn impacts brain tumor development.
Congratulations to all authors: Francesca Romana Stefani, Sofia Eberstål, Stefano Vergani, Trine A. Kristiansen and Johan Bengzon!
Congratulations Mehrnaz Safaee Talkhoncheh, Aurélie Baudet and Jonas Larsson, Division of Molecular Medicine and Gene Therapy, on the publication of your work "Transient Inhibition Of NF-ΚB Signaling Enhances Ex Vivo Propagation Of Human Hematopoietic Stem Cells" in Haematologica.
In this study, the authors have shown that chemical inhibition of the NF-kB signaling pathway facilitates the propagation of human hematopoietic stem- and progenitor cells in culture.
This work will also lay the foundation for Mehrnaz' doctoral dissertation which is scheduled for November 2018.
Congratulations to all authors!