Tid: 2019-03-20 Kl 09:00
Sluttid: 2019-03-21 Kl 14:00
Plats: Agardh lecture hall, CRC, Jan Waldenstöms gata 35, SUS Malmö
Kontakt: Sara Liedholm, firstname.lastname@example.org
The large-scale genome-wide association studies significantly contributed to the identification of a substantial number of genetic variants associated with complex metabolic conditions such as obesity and diabetes. Nevertheless, given that many of the genomic loci reside in the non-coding regions it is very difficult to design appropriate biological experiments for functional validation. Recent evidence from a number of successful examples from genotype-based recall demonstrated not only validity of the genomic discoveries and but also illuminated novel biological mechanisms through detailed targeted physiological investigations in these extreme individuals. How to unmask the most impactful categories of phenotypic and genotypic extremes will be discussed during our joint LUDC/UiB/FIMM meeting “Extremism can be useful” at CRC in Malmö, CRC.