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The half-time review will be held at 1 p.m. (13:00 h) on April 5th at Bioforum, building 406, Medicon Village, Lund

PhD student: Renée Daams

Examiners: Prof. Ewa Sitnicka Quinn and Assoc. Prof. Anna-Karin Larsson Callerfelt

Supervisor: Prof. Ramin Massoumi

Co-supervisors: Prof. Karin Leandersson and Prof. Anette Gjörloff Wingren

The role of the Wnt signaling pathway in development and disease

The Wnt signaling pathway regulates various cellular processes, including cell growth, cell survival, cell differentiation, cell fate determination, and is responsible for organ homeostasis in mammals. Activation of Wnt signaling, leads to the disruption of a destruction complex consisting of Axin, adenomatous polyposis coli (APC), casein kinase 1 (CK1), and glycogen synthase kinase 3 beta (GSK3β), resulting in stabilization of β-catenin, followed by nuclear translocation and binding to t-cell factor/lymphoid enhancer-binding factor (TCF/LEF) for target gene transcription. Inhibition of the Wnt signaling pathway can be achieved by phosphorylation of β-catenin, resulting in subsequent ubiquitination and proteasomal-mediated degradation. Previous studies have shown that aberrant Wnt signaling is involved in the development and progression of multiple diseases. The projects covering this half-time review consist of using in vivo and in vitro models generated towards analyzing the function of Wnt signaling components in lymphocytes and tumor cells under conditions such as fibrosis and cancer. By elucidating the function of Wnt signaling in chronic inflammation and cancer, we will gain knowledge that can be put toward generating new approaches to target these diseases and creating novel therapeutic reagents.

Published paper included in half-time review: Masoumi KC, Daams R, Sime W, Siino V, Ke H, Levander F, and Massoumi R. NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling. Molecular biology of the cell. 2017; 28 (2):346-55