Molecular Neuromodulation

Faculty of Medicine | Lund University

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Molecular Neuromodulation

Cell transplants in a rat model of Parkinson's Disease
Cell transplants in a rat model of Parkinson's Disease with in vivo recording of DREADD-induced DA release

Contact information

Dr Tomas Bjorklund
Assistant Professor

Molecular Neuromodulation
Wallenberg Neuroscience Center
BMC, A10 22184 Lund
Sweden

Phone: +46 46 222 68 36 

tomas.bjorklund@med.lu.se

Visiting address

Molecular Neuromodulation
Wallenberg Neuroscience Center
BMC, A10 Sölvegatan 17 Lund
Sweden

Directions and further info


Molecular Neuromodulation (MNM), established in 2011 under the leadership of A/Prof Tomas Björklund, is a research group within the Wallenberg Neuroscience Center. We focus on the development and application of disruptive technologies for in vivo gene editing (CRISPR/Cas9 and other technologies) and connectivity mapping as well as on the development of next-generation gene based therapies for Parkinson’s disease and related disorders. 


MNM participation at the Society for Neuroscience 2016
MNM participation at the Society for Neuroscience 2016

We are currently looking for bright, motivated people to join the group both at the PhD and the PostDoc level in the fields of molecular biology, in vivo studies and bioinformatics. Please check out The Opportunities.

News

Over the last four years we have in MNM worked very hard to develop a novel technique for viral vector barcoding and the generation of highly diverse libraries for detailed assessment of biological functions in vivo. Applications of this technique are near endless with obvious applications in both connectomics and the generation of novel viral vector serotype. The road has been long and winding but it is now bearing exciting fruit. The first paper in this research line is now finally published in Scientific Reports. Congratulations to first author Marcus Davidsson! A couple of very cool applications are now well under way to be published. Keep your eyes open and watch this spot...

Read the paper here: http://rdcu.be/mQ1x

At the Society for Neuroscience meeting in San Diego, MNM representatives Tomas Bjorklund, Marcus Davidsson and Patrick Aldrin-Kirk presented recent progress on ongoing research topics. Patrick presented a posted summarising our recent Neuron paper on mechanisms underlying Graft-induced dyskinesias which raised significant interest. Tomas and Marcus presented the exciting development in the group on the generation of synthetic AAV serotype with unique properties at a very well attended symposium on the topic of "Genetic tehniques" (Chaired byTomas and Ben Deverman, UC Berkley)

MNM is the proud recipient of two Swedish Research Council Starting Grants awarded to PI Tomas Bjorklund and to Andreas Heuer who recently joined the group as a senior PostDoc.

The AAV-based alpha-synuclein over-expression model is an emerging disease model for Parkinson's disease with hig potential to deliver a better progressive model that recapitulates the major hallmarks of the disease. In this 2-year project MNM will work together with A/Prof. Fredric Manfredsson at Michigan State University to establish a transferrable and reproducible animal model.

We sincerely welcome Dr Andreas (Andi) Heuer to MNM. Andi Heuer Completed his PhD with Prof. Steve Dunnett in Cardiff and has been a PostDoc with Prof. Malin Parmar at Lund University with close collaboration with MNM. This resulted in the 2016 Neuron paper found elsewhere on this page. Andi's research interests include the therapeutic potential of hESC transplants in PD towards complex behavior and cognition and in vivo recordings linked with Optogenetic and Chemogenetic modulation. 

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