Molecular Neurogenetics

Faculty of Medicine | Lund University

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Publications

2018

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Hult Lundh S, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J

openaccess

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation
Cell Reports 24, 1397–1406, August 7, 2018


Grassi DA, Jönsson ME, Brattås PL, Jakobsson J.
TRIM28 and the control of transposable elements in the brain
Brain Res. 2018 Mar 6.


Petri R, Jakobsson J
Identifying miRNA Targets Using AGO-RIPseq
Methods Mol Biol. 2018;1720:131-140


2017

Drouin-Ouellet J, Pircs K, Barker RA, Jakobsson J, Parmar M.

openaccess

Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?
Front Neurosci. 2017 Sep 28


Brawek B, Liang Y, Savitska D, Li K, Fomin-Thunemann N, Kovalchuk Y, Zirdum E, Jakobsson J, Garaschuk O

openaccess

A new approach for ratiometric in vivo calcium imaging of microglia.
Sci Rep. 2017 Jul 20;7(1):6030


Drouin-Ouellet J, Lau S, Brattås PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjöland A, Westergren-Thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M

openaccess

REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
EMBO Mol Med. 2017 Jun 23.


Petri R, Pircs K, Jönsson ME, Åkerblom M, Brattås PL, Klussendorf T, Jakobsson J
let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy
EMBO Journal. 23 March 2017.


Alcacer C, Andreoli L, Sebastianutto I, Jakobsson J, Fieblinger T, Cenci MA

openaccess

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson's disease therapy
J Clin Invest. 2017 Jan 23.


Brattås PL, Jönsson ME, Fasching L, Nelander Wahlestedt J, Shahsavani M, Falk R, Falk A, Jern P, Parmar M, Jakobsson J

openaccess

TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells
Cell Reports. January 3rd, 2017


2016

Malmevik J, Petri R, Knauff P, Brattås PL, Åkerblom M, Jakobsson J

openaccess

Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.
Sci Rep. 2016 Jan 27;6:19879


2015

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Björk Wilhelms D, Lazarus M, Löfberg A, Jaarola M, Örtegren Kugelberg U, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Rodriguez Parkitna J, Saper CB, Blomqvist A, Engblom D

openaccess

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice
Journal of Clinical Investigation. 2015 Dec 21. pii: 83844.


Jönsson ME, Nelander Wahlestedt J, Åkerblom M, Kirkeby A, Malmevik J, Brattaas PL, Jakobsson J, Parmar M

openaccess

Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor
Development. 2015 Sep 15;142(18):3166-77.


Malmevik J, Petri R, Klussendorf T, Knauff P, Åkerblom M, Johansson J, Soneji S, Jakobsson J

openaccess

Identification of the miRNA targetome in hippocampal neurons using RIP-seq
Scientific Reports 5, Article number: 12609 (2015). Published online: 28 July 2015


Grealish S, Heuer A, Cardoso T, Kirkeby A, Jönsson M, Johansson J, Björklund A, Jakobsson J, Parmar M

openaccess

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons
Stem Cell Reports. 2015 May 20


Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson M E, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J

openaccess

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
Cell Reports, 2015 Jan 6;10(1):20-8


2014

Lau S, Ryllander Ottosson D, Jakobsson J, Parmar M

openaccess

Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors
Cell Reports, Volume 9, Issue 5, p1673–1680, 11 December 2014


Åkerblom M, Petri R, Sachdeva R, Klussendorf T, Mattsson B, Gentner B, Jakobsson J

openaccess

microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons
Development. March 5, 2014


2013

Malmevik J, Åkerblom M, Jakobsson J
microRNA and Neurodegenarative diseases
book chapter in: microRNAs in Toxicology and Medicine, editor Saura C. Sahu, October 2013

Petri R, Malmevik J, Fasching L, Åkerblom M, Jakobsson J
miRNAs in brain development
Experimental Cell Research. 2013 Oct 4

Åkerblom M, Jakobsson J
MicroRNAs as Neuronal Fate Determinants
Neuroscientist. 2013 Jul 22.

Decressac M,  Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
PNAS April 22, 2013

Åkerblom M, Sachdeva R, Quintino L, Elgstrand Wettergren E, Chapman K Z, Manfre G, Lindvall O, Lundberg C, Jakobsson J
Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9
Nature Communications 4, Article number: 1770. 23 April 2013.

Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Björklund A, Grealish S, Parmar M
Generation of induced neurons via direct conversion in vivo
PNAS, March 25, 2013

2012

Rowe H M, Kapopoulou A, Corsinotti A, Fasching L, Macfarlan TS, Tarabay Y, Viville S, Jakobsson J, Pfaff S L, Trono D
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
Genome Research, December 10, 2012.

Åkerblom M, Sachdeva R, Barde I, Verp S, Gentner B, Trono D, Jakobsson J
MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant
Journal of Neuroscience. 27 June 2012, Volume 32, Issue 26, pp 8879 to 8889

Åkerblom M, Sachdeva R, Jakobsson J
Functional studies of microRNAs in neural stem cells: problems and perspectives
Frontiers in neurogenesis. 07 February 2012.

2011

Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D.
In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions.
Mol Cell. 2011 Nov 4;44(3):361-72.

Grealish S, Jakobsson J, Parmar M.
Lineage reprogramming : A shortcut to generating functional neurons from fibroblasts. 
Cell Cycle. 2011 Oct 15;10(20):3421-2

Parmar M, Jakobsson J
Turning skin into dopamine neurons
Cell Research advance online publication 9 August 2011

Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M.
Direct conversion of human fibroblasts to dopaminergic neurons.
Proc Natl Acad Sci U S A. 2011 Jun 6.

Kirkeby A, Parmar M, Jakobsson J
Using endogenous microRNA expression patterns to visualize neural differentiation of human pluripotent stem cells
Methods in Molecular Biology, 2011 Jul 30.

2010 

Sachdeva R, Jönsson M, Nelander J, Kirkeby A, Gentner B, Naldini L, Björklund A, Parmar M and Jakobsson J.
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.  
PNAS  2010 Jun 22;107(25):11602-7.
 

Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D.
KAP1 controls endogenous retroviruses in embryonic stem cells. 
Nature   2010 463:237-40
 

2009 

Tolstrup Nielsen T, Jakobsson J, Rosenqvist N and Lundberg C.
Incorporating double copies of a chromatin insulator into lentiviral vectors results in less lentiviral integrants.  
BMC Biotechnology, 2009 9:13
 

2008

Jakobsson J,  Cordero MI, Bisaz R, Busskamp V, Bensadoun JC, Cammas F, Losson R, Mansuy IM, Sandi C and Trono D.
KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress. 
Neuron, 2008 60:818-31
 

Lundberg C, Björklund T, Carlsson T, Jakobsson J, Hantraye P, Déglon N and Kirik D.
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.  
Current Gene Therapy, 2008 8:461-73
 

2007

Wiznerowicz M, Jakobsson J,  Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P and Trono D.
The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis.  
Journal of Biological Chemistry  2007 282:34535-4
 

2006

Jakobsson J, Rosenqvist N, Marild K, V Agoston D and Lundberg C.
Evidence for disease-regulated transgene expression in the brain with the use of lentiviral vectors.  
Journal of Neuroscience Research    2006 84 :58-67  
 

Jakobsson J and Lundberg C.
Lentiviral vectors for use in the central nervous system.  
Molecular Therapy  2006 13:484-93
 

Jakobsson J, Tolstrup Nielsen T, Staflin K, Georgievska B and Lundberg C.
Efficient transduction of neurons using Ross River glycoprotein pseudotyped lentiviral vectors.  
Gene Therapy  2006 13:966-73
 

2005

Rosenqvist N, Jakobsson J and Lundberg C. 
Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain.  
Cell Transplantation   2005 14:129-38
 

2004

Georgievska B, Jakobsson J, Persson E, Ericson C, Kirik D and Lundberg C.
Regulated delivery of GDNF in the rat striatum using a tetracycline-dependent lentiviral vector.  
Human Gene Therapy  2004 15:934-44     
 

Jakobsson J, Rosenqvist N, Thompson L, Barraud P and Lundberg C.
Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4-insulator.  
Experimental Cell Research 2004  298 : 611-23   
 

Jakobsson J,  Georgievska B, Ericson C and Lundberg C (2004)
Lesion-dependent regulation of transgene expression using a human glial fibrillary acidic protein-lentiviral vector.  
European Journal of Neuroscience  2004 19:761-5
 

2003

Jakobsson J, Ericson C, Jansson M, Bjork E and Lundberg C. 
Targeted transgene expression in the rat brain using lentiviral vectors.  
Journal of Neuroscience Research  2003  73:876-85
 

Jakobsson J, Ericson C, Rosenqvist N and Lundberg C.
Lentiviral vectors.  
International Reviews in Neurobiology  2003 55:111-22
 

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