Developmental Biology, Baumgartner Lab

Faculty of Medicine | Lund University

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Lab of Stefan Baumgartner

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Evidence of a bicoid mRNA gradient refutes the SDD model which proposes that the Bicoid protein gradient arises through diffusion of the Bicoid protein.  Read also our 2009 paper and our recent paper (2014) on how the bicoid mRNA is transported in the embryo to the posterior.  Also read how, with the help of microtubules and the motor protein Ncd, the bicoid mRNA gradient is formed which is then the template for translation to form the protein gradient.

Read also a 2009 Nature Molecular Cell Biology review on the bicoid story, or a description of the whole story in a somewhat more gossip style in LabTimes here.

Watch 2 YouTube movies on bicoid mRNA gradient formation:

How the bicoid mRNA gradient evolves

The transition from basal to apical expression during nuclear cycle 14

bcd mrna protein

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Lund University
Dept. of Experimental Medical Sciences
BMC D10
22184 Lund
SWEDEN

Tel Lab: +46 46 222 3006

or           +46 46 222 3893

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