Photo: Kennet Ruona/Malin Parmar
My group works with translational stem cell biology. The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells using cell-based models of neuronal differentiation. Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons. We also develop technologies for direct conversion of human fibroblasts into functional and subtype-specific neurons in vitro, and the conversion of endogenous glia into neurons in vivo.
The ultimate aim is to develop these cells and technologies for use in brain repair, with focus on Parkinson’s disease.
2017-06-26. Are you interested in progress on large-scale production of living brain cells? You can find out more in our latest paper REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
- Lund University's press release: Genombrott i cellfabriken – Upptäckt kan ge ny inblick i sjukdomar som Alzheimers och Parkinsons
2017-03-17. Today we took part in UniStem Day 2017, together with dozens of other universities around Europe. UniStem is an annual event for the dissemination and outreach of stem cell science and research, conceived at the University of Milan. It is targeted to high school students and involves the collaboration of Universities as organising Entities. Fore more information about the event, please go to:
2017-03-15. Celebrating the 10th anniversary of the European Research Council (ERC), we participated today in a mingle with ERC-winning research teams from Lund University. The event was organized by Research Services in conjunction with the “ERC Week”.
2017-01-04. We're happy to announce that Malin Parmar has been awarded the Swedish Research Council (SRC) Consolidator Grant! Over the coming 6 years she will receive 11 million SEK for her project “In vivo reprogramming: a new way to repair the brain".
- Lund University's press release
2016-10-28. Learn more about our exciting new discoveries presented in two scientific articles which deals with the production of dopamine cells for Parkinson's as well as the road to the first patient transplant. The publications reflect two aspects of the same process: how these important cells develop in a healthy body, and how they can be developed in a laboratory to be inserted into a diseased body.
På svenska: Läs mer om våra nya spännande upptäckter som presenteras i två vetenskapliga artiklar och avhandlar tillverkning av dopaminceller för Parkinsons samt vägen fram till den första transplantationen på människa. Publikationerna återspeglar två aspekter av samma process: hur dessa viktiga celler utvecklas i en frisk kropp, respektive hur de kan utvecklas i ett laboratorium för att föras in i en sjuk kropp.
- Lund University's press release
- Lunds Universitets pressmeddelande
- Förbättrad tillverkning av dopaminceller för Parkinsons | Lunds universitet copy (pdf 107,5 kB)
- Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease
- Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages
Authors at Lund University