Yvonne Lundberg Giwercman is associate professor in experimental urology. Her research includes molecular studies on gene variants with the aim to try to understand hereditary differences regarding both the normal states as states of illness.
One example is prostate cancer testing, which to diagnose the disease you first measures the level of PSA (prostate specific antigen) in the blood. We have shown that a genetic variant of the androgen receptor, which is the molecule that mediates the effect of testosterone, influences how high the PSA concentration is. In healthy men without prostate cancer, or men with less aggressive cancers, the gene variant has significance for the risk you run to undergo biopsy for PSA testing. This can also lead to that healthy men with elevated PSA or asymptomatic men are recommended prostate biopsy and eventually treatment for cancer.
The purpose of the current study is to investigate whether the gene variant can be used to improve the PSA testing.