Translational Medicine

Faculty of Medicine | Lund University

Mix of antibiotics powerful against infectious disease

2017-08-03

Portrait photo of Magnus Paulsson. Photo: Björn Martinsson

Pseudomonas aeruginosa is an opportunistic bacterium and a deadly threat against patients suffering from severe disease. A new study from Lund University presents a highly effective treatment by combining two antibiotics.

- This combination was effective over different ages and also valid for a range of infections, among these pneumonia and urinary tract infection. Hospitals around the world can put these results into practice immediately, states Magnus Paulsson, doctor of philosophy in medical science at Lund University and MD at Skåne University Hospital.

Pseudomonas aeruginosa is often highly resistant against commonly used antimicrobial drugs.

The findings are part of a new thesis which also includes studies of mechanisms used by Pseudomonas aeruginosa in order to colonize the human body.

In focus is the role of outer membrane vesicles (OMV) which are nanoparticles released from Gram-negative bacteria such as Pseudomonas aeruginosa.

Magnus Paulsson in his thesis for the first time brings forward convincing evidence for the role of already known Pseudomonas aeruginosa strategies in order to invade the lungs.

Another study sheds light upon how Pseudomonas aeruginosa-vesicles gain help from Moraxella catarrhalis-vesicles and become successful in the spreading of infection to remote parts of the body.

Magnus Paulsson put forward his thesis ”Host-pathogen interactions in Pseudomonas aeruginosa invasive and respiratory tract infection” at The Department of Translational Medicine, Lunds University on 24 May 2017.

Text and photo: Björn Martinsson

 

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