Tumor Microenvironment

Faculty of Medicine | Lund University

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Tumor Microenvironment

Belting Group

We use advanced experimental models in conjunction with studies on patient derived materials, and clinical intervention studies to investigate the role of stress-related phenomena of the tumor microenvironment, such as hypoxia, acidosis and coagulation activation, as treatment targets and biomarkers of cancer.

Stress factors are early and potent drivers of cancer progression providing a strong selection pressure that is associated with intrinsic resistance to conventional oncological treatments and decreased patient survival. A more detailed understanding of tumor cell adaptive responses is critical for the design of more rational therapeutic strategies of cancer. Our recent findings (e.g. Christianson, et al., PNAS, 2013; Kucharzewska, et al., PNAS, 2013; Menard, et al., Cancer Res., 2016) indicate a novel role of lipoproteins and extracellular vesicles in the communication between cancer cells and stromal cells of the tumor microenvironment.

In ongoing projects, we pursue original ideas of how malignant cells respond to and cope with stress factors with the goal to develop new treatment concepts in the fight against cancer. Our studies are focused on but not limited to glioblastoma (GBM), i.e. primary brain tumors characterized by a chaotic microenvironment and associated treatment resistance. We have recently developed a method for functional mapping of the cancer cell-surface proteome (Bourseau-Guilmain, et al., Nat Comm., 2016) for the identification and targeting of tumor antigens of the treatment-resistant tumor niche. The insights from ongoing studies may fundamentally change the way it is perceived how malignant cells and tumor stromal cells adapt to microenvironmental stress with the potential to provide more rational treatments of GBM and other types of aggressive cancers.

Lund University YouTube Channel "Cancer cells' communication path blocked"

Contact

mattias belting

Mattias Belting, MD/PhD
Professor of oncology
Senior consultant of oncology

Department of Oncology and Pathology
Clinical Sciences
Barngatan 4
Lund University
SE-221 85 Lund, Sweden

Phone (office): +46 +46 17 85 49

+46(0)733507473

E-mail: Mattias.Belting@med.lu.se

Fax: +46 +46 17 60 23

Good news

Belting group and collaborators provide new insight into how cancer cells adapt to stress factors of the tumor microenvironment through increased uptake of lipoproteins, resulting in a lipid storing phenotype, and enhanced tumor forming capacity.

Menard JA, et al. Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis. Cancer Research (2016) 76:4828-40.

http://cancerres.aacrjournals.org/content/

http://www.med.lu.se/nyheter/160524/

https://www.svt.se/nyheter/lokalt/skane/

Belting group and collaborators find that hypoxia modulates global membrane proteome turnover in cancer cells, providing opportunities for tumor specific drug delivery.

Bourseau-Guilmain E, et al. Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells. Nature Communications (2016) 7:11371.

https://www.nature.com/articles/

http://www.medicalnewstoday.com/releases/

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