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Applied statistics II - Clinical Research

Course leaders
Course 1 
Pär-Ola Bendahl,, Associate professor, Clinical sciences Lund, department of oncology and pathology

Course 2:
Anton Nilsson,

Jonas Björk

Target group
PhD-students at the medical faculty with a research project within clinical research. Passed course Applied statistics I is required together with basic knowledge in the statistical package used in the same course.

Autumn 2021
Week 46-47 in English
Week 48-49 in English
Spring 2021
Week 12-13 - in Swedish. This course will be given digitally.
Week 18-19 + home exam Mo and Tue week 20 (due to holiday in Sweden part of week 19) - This course will be given digitally in English.

Note that 3 hp amounts to 2 weeks of fulltime study, both regarding credits and  the actual extent, and that attendance is compulsory for all course days.

3 hp

Please note that the two courses spring 2021 will be given digitally.

Content of the course
The course includes the following four blocks:

1. Design and analysis of studies with a focus on binary outcomes
• Cohort and case-control studies
• Incidence and risk measures
• Measures of association: Odds ratio, absolute and relative associations
• Basic  survival problems (time-to-event)
• Power

2. Introduction to correlation- and regression analysis
• Spearman’s and Pearson’s correlation coefficients
• Simple linear regression
• Simple logistic regression

3. Regression analysis - advanced
• Introduction to Cox regression
• Multivariable modelling
• Interaction

4. Randomized Controlled Trials (RCT) and diagnostic studies
• Design and analysis of randomized controlled trials
• Diagnostic measures: sensitivity, specificity, predictive values
• ROC-analysis

This course for clinical researchers focuses on regression methods, especially linear regression models for a continuous outcome variable and one or more independent variables: in what situations they can be used and how the results should be interpreted.

The course will also cover how regression methods can be used to assess and handle confounding and interaction. Further, other types of regression models such as for binary outcomes (logistic regression) and survival analysis (Cox regression) will be introduced. Additionally, statistical methods for diagnostic tests will be covered by introducing sensitivity, specificity, positive and negative predictive value, as well as choice of cut off with ROC-analysis. The course also introduces theory and regulations around randomized controlled trials.

Course literature
Kirkwood B and Sterne J. Essential Medical Statistics. Blackwell Science, 2nd edition, 2003. Chapter: 10-16, 18-22, 26-27, 29, 34-38.

Available as e-book at Lund University Libraries (
The course will be held in English and requires active participation and access to laptop with installed statistical package that you are familiar with from earlier courses (SPSS, STATA or R). More information will be provided before the course.


Last day for application for compulsory courses autumn 2021, is March 18.


If questions about available course spots, please contact Anette Åkerberg at:

Course coordinator:

Jonas Björk
E-mail: and

Helena Jernström

Contact Jonas or Helena if you have general questions concerning the faculty statistics courses at the graduate level.
This also applies to any requests regarding credit transfer.

Please contact the course leaders if questions about schedule issues, in the event of absence and other things that are directly related to the course.

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