Professor Ramin Massoumi at the Division of Translational Cancer Research has just purchased a new instrument. The price tag? Five million SEK. The new technology is called IVIS-CT and is used for following various diseases in real time in live small animals. This gives researchers knowledge of complex biological systems by enabling molecular and anatomically non-invasive imaging of animal organs. In this way, one can compare different treatment methods and diagnostic values without having to euthanise the animals.
- There are not many in Europe who have access to such a unique instrument and it is a huge asset in preclinical research, says Ramin Massoumi.
Without IVIS-CT, the researcher cannot follow the disease from day one and this means that a larger number of animals are required since you cannot predict which animals will develop the disease or respond to treatment. It is also impossible for the researcher to know what is happening during the treatment period, which can range from months to years. When the experiment is over, the animal is euthanised and only then can you see if the treatment has had an effect.
- But with IVIS-CT, significantly fewer animals are needed because the same animal is followed throughout the entire period and the animal is only anesthetized during imaging. This saves not only the number of animals but also time, money and energy.
In this way, IVIS-CT is completely in line with the 3R principle, which today permeates both Swedish and European legislation for animal experiments: Replace, Refine and Reduce. The IVIS-CT is available to all researchers within the Faculty of Medicine or other faculties within the university. The instrument can be rented on an hourly basis and includes support in producing and analyzing images and results. For more information contact Ramin Massoumi.
The IVIS-CT was paid for by Mats Paulsson at Medicon Village (2.5 million), the Lundberg Foundation (2 million) and the Crafoord Foundation (0.5 million).
Text: Åsa Hansdotter