Jia-Yi Li, professor, group leader
Neural Plasticity and Repair group
Our main interest is to study pathogenetic mechanisms of Parkinson’s and Huntington’s diseases and seek for strategies of therapeutic inventions to the diseases.
We are currently working with following projects:
1. Pathogenetic mechanisms of neurodegenerative diseases, especially Parkinson’s and Huntington's diseases. The research line mainly focuses on synaptic dysfunction, axonal degeneration and aberrations of synaptic plasticity.
2. Stem cell therapy for transplantation purposes in Parkinson's disease. The research line aims to enhance cell survival, preserve specific neuronal phenotype, enhance axon outgrowth and improve functional integration.
3. Neurogenesis during development and in adulthood and in diseased conditions
4. Neuroinflammation, especially microglia, in disease onset and progression of Parkinson’s and Huntington’s diseases.
5. Intraneuronal trafficking (axonal transport) of membrane-associated proteins and alterations in neurodegenerations.