The ability to sense and respond to danger is a fundamental property of eukaryotic cells. In the battle against invading pathogens, such detection is of crucial importance for host protection. The Host-Pathogen Interactions group is currently focusing on the Gram-positive extracellular bacteria Streptococcus pyogenes and Staphylococcus aureus, and the processes by which these pathogens interact with the immune system. We are particularly interested in microbial interactions with innate immunity, and what effects such interactions might have on subsequent adaptive immune processes.
Some of the questions we are interested in are:
- How do immune cells detect and respond to invading pathogens?
- How do bacterial pathogens evade or exploit the immune system to promote survival and colonization?