Experimental Medical Science

Faculty of Medicine | Lund University


Host-Pathogen Interactions

The ability to sense and respond to danger is a fundamental property of eukaryotic cells. In the battle against invading pathogens, such detection is of crucial importance for host protection. The Host-Pathogen Interactions group is currently focusing on the Gram-positive extracellular bacteria Streptococcus pyogenes and Staphylococcus aureus, and the processes by which these pathogens interact with the immune system. We are particularly interested in microbial interactions with innate immunity, and what effects such interactions might have on subsequent adaptive immune processes.

Some of the questions we are interested in are:

- How do immune cells detect and respond to invading pathogens?

- How do bacterial pathogens evade or exploit the immune system to promote survival and colonization? 

host pathogen interactions group

Selected Funding

Selected Publications

Byrne BG, Dubuisson J-F, Joshi AD, Persson JJ, Swanson, MS. Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection. MBio. Feb 12(4). 2013.

Lightfield KL*, Persson J*, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE. Differential requirements for NAIP5 in activation of the NLRC4 (IPAF) inflammasome. Infection and Immunity. 79:1606-14. 2011. *These authors contributed equally

Lightfield KL*, Persson J*, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nature Immunology. 9:1171-8. 2008. *These authors contributed equall

Persson J, Vance RE. Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence. Immunogenetics. 59:761-78. 2007.

Persson J, Beall B, Linse S, Lindahl G. Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein. PLoS Pathogens. 2:e47. 2006.

Site overview