We are interested in a population of cells belonging to the innate immune system, eosinophils. Eosinophils reside continuously in several tissues, including the gastrointestinal tract and adipose tissue. Although predominantly viewed as a proinflammatory cell type associated with allergic reactions and parasite infection more recent data, including our own, suggest that eosinophils participate in other processes, including regulatory functions under homeostatic conditions. Our research projects are aimed at better understanding basic eosinophil biology, and defining their contribution to immune processes during homeostasis and inflammation.
Our second line of interest investigate how immune responses are evoked against infection with gastrointestinal nematodes – a group of pathogens that are rare in our part of the world, but that are highly interesting as they are capable of modulating the immune system of their hosts.
Our projects are aimed at defining how the parasite itself and its secreted products are recognized by and interact with the immune system, which immune cells that are involved, and how the interaction affects the ensuing immune response.
- Role of intestinal eosinophils in the intestinal mucosa during IBD
- Regulation of vascular function by adipose tissue eosinophils
- Generation of T helper 2 responses during nematode infection
- Role of the inflammasome in recognition of nematode infection
- Immunomodulatory function of nematodes and their secreted products