Experimental Medical Science

Faculty of Medicine | Lund University


Chemical Biology and Therapeutics

CBTs research is focused on neuropharmacology using zebrafish and locust as models. 

Zebrafish in neuropharmacology research

We are interested in finding and exploring activity patterns in neurodegenerative and neuropsychiatric diseases on a single cell level and correlate these network patterns with behavior (e.g., locomotors activity and cognition) with focus on brain lateralization. We are using high-speed imaging tracking technology, detailed multivariate behavioral analysis, and selective plan imaging microscopy (SPIM) of live zebrafish.


Multidimensional evaluation of drugs using multivariate analysis. We have established an infrastructure for behavioral analysis of zebrafish larvae, up to 192 zebrafish in parallel in microtiter plates and shoaling behavior of groups of zebrafish.

Locust model for BBB studies


An ex-vivo model where the brain is isolated from a locust and kept in a vial at room temperature for several hours without losing the BBB integrity and enzymatic activity.

The development of effective central nervous system (CNS) drugs able to reach the desired regions of the brain has been problematic because the brain is protected very effectively by the blood-brain barrier (BBB). Therefore, a great body of research has focused on predicting the BBB penetration of potential CNS drugs.


Roger Olsson

Department of 
Experimental Medical Science 
Lund University BMC D10
SE-221 84 Lund, Sweden

Mobile:+46 076 887 42 17 

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