Center for Cardiac Arrest

Faculty of Medicine | Lund University

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Projects

Emergency and pre-hospital care

Early identification of cardiac arrest and early CPR are critical for survival. We hope to shorten response times and increase survival by analyzing emergency calls to the SOS Alarm Centre and evaluate early efforts from bystanders, volunteer life-savers, and the medical emergency services.

Studieinformation till Dig som har drabbats av hjärtstopp utanför sjukhus i Skåne mellan åren 2010-2016:

 

Contact: Hans Friberg


Assessment of brain injury and prognosis for recovery

A continuous assessment of brain damage is being performed after cardiac arrest using different prognostic instruments. The tools being used include repeated neurological examinations, neurophysiological methods (continuous EEC and SSEP), imaging diagnostics (CT, MRI) and biochemical markers in the blood for brain and heart damage, including NSE.

Contact: Tobias Cronberg


SWECRIT – a biobank for critically ill patients

Since 2014 blood samples have been collected from critically ill patients in Intensive Care Units in Skåne and from healthy volunteers. Our plan is to include more than 3000 patients and healthy volunteers annually in SWECRIT. The samples will be stored in a biobank owned by Region Skåne until they are analyzed. The project aims to investigate genetic variations and differences in circulating substances in blood in patients with severe critical illness to better predict the outcome, but also to optimize treatment and prevent disease.

Contact: Hans Friberg


Follow-up of cognitive function and quality of life in survivors

We have implemented a standardized model for follow-up of survivors after two and six months for assessment of cognitive function, quality of life and rehabilitation needs. In addition, the family members' situation and need for support are included in the follow up. The model has been used in the TTM-trial and our plan is to test if the model leads to improved quality of life and improved numbers of patients going to work in a new international, randomized trial.

Contact: Tobias Cronberg


Target Temperature Management after Cardiac Arrest (the TTM-study)

The TTM-study evaluated the effect of two different target temperatures, 33˚C and 36˚C, after out-of-hospital cardiac arrest. In total 950 patients were randomized at 36 hospitals in 10 countries. A target temperature regimen 33°C did not confer a benefit compared to maintaining a temperature of 36°C. A large number of sub-studies evaluating the influence of temperature on awakening, seizures, EEG patterns, release profile of brain damage markers, cognitive function, quality of life and prognostic accuracy have been completed, and work continues. Our TTM-biobank with more than 20000 samples has partly been analyzed. A follow-up study, TTM-2, is planned to start in 2017. An investigator meeting was held on November 22nd in Lund. Please see the minutes and presentations from the meeting:

Contact: Niklas Nielsen


The International Cardiac Arrest Registry (INTCAR)

INTCAR (previous name Hypothermia Network Registry) is an observational collaborative project between hospitals on both sides of the Atlantic, which has been on-going since 2004. Treatment data from more than 6000 cardiac arrest patients are collected in a common database allowing comparative analysis of cardiac arrest care in Europe and the US. More information on www.intcar.org

Contact: Niklas Nielsen 

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