Lund University Bioimaging Center

Faculty of Medicine | Lund University

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Preclinical Nuclear Medicine

Our platform is open for both internal and external users. The LBIC PET/SPECT/CT platform is housed at BMC A09 and is equipped with a nanoPET/CT and a nanoSPECT/CT.

CT

CT (computed tomography) is a non-invasive technique that provides a detailed 3-D image. The same object can be imaged multiple times on different occasions to study the development of your treatment/disease model. CT uses the density difference in the object to create images of resolution down to 10 µm.

To the the right you see micro-X-ray imaging.
The head of a hip-joint (caput femoralis) from a mouse.
Diameter of the head is 1.3 mm.
CT images: slice thickness 0.01 mm, voxel-size 0.01 x 0.01 mm.

Using a radioactive tracer, physiological phenomena can be followed and functional images are created. Your biomolecule, labelled with a radioactive nuclide, is injected into the object to follow where it accumulates and how fast. The acquired intensity maps are then superimposed on the CT picture for easier image analysis.

PET

PET imaging uses isotopes which decay by β+, these usually have short half-life. This technique is advantageous for shorter processes and can also be used by multiple administrations of the tracer.

To the right you see accumulation of the PET-tracer FE-PE2I in the striatum of a rat brain.
Courtesy of Deniz Kirik.

SPECT

SPECT imaging uses photons emitted from radioactive decay, for photon energies 25-350 keV. These isotopes usually have longer half-life, and the technique is advantageous for long processes as well as radiotherapy studies. Due to the difference in photon energy from different isotopes, more than one process can be monitored simultaneously.

foerstasida preclin nuclear med

If you are interested in doing a project with us please contact the platform coordinator: Ritha.Gidlof@med.lu.se

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