The Neuronano Research Center (NRC) has been active since 2006.
In 2011, the 5 year goals of the 10 year Linnaeus Grant period have been achieved: to develop novel micro- and nanometer sized neural interfaces that meet the requirements of advanced neurophysiological applications and to develop a neuroinformatics infrastructure that makes possible analysis of the huge data amount obtained from the novel neural interfaces. The research process at NRC is developing in interplay with technological innovation. Accordingly, IPRs for novel research tools and applied devices for clinical use have been systematically secured.
With regard to methodology and technological platforms we have acted proactively, i.e. focused on foreseeing upcoming requirements and bottle necks:
- To meet the rapidly escalating demand for computational power and analytical tools we have implemented an overall neuroinformatics infrastructure to match future neural interfaces, with an increasing number of channels that will generate vast amounts of highly complex data. Already with 32-64 channels as in the first generation of NRC electrodes, information received from a single animal is daunting.
- To meet the upcoming demands in neurophysiology for technology platforms, we have equipped the laboratories with in state of art instruments and are now well equipped for the next 5 years with 3 set-ups for multichannel recordings; one set up for multichannel telemetric recordings; one lab for combined electrophysiology and in vivo 2 photon microscopy; and one additional in vitro laboratory with fluorescence imaging and electrophysiology equipment for in vitro tests of effects of nanomodified surfaces, drug release from nanoparticles and effects of different electrode materials.
- To meet the demands in long term biocompatibility assays our labs are now fully equipped for quantitative histology and in-situ hybridization. We have also developed software for combined behavioral monitoring and multichannel recordings in awake, freely moving animals. In addition, we have access to state of art nanotechnology and advanced photolithographical methods.