Dr. Kyra Gelderman

Curriculum Vitae

1976: Born in Enschede, The Netherlands

1994-1999: Biology, Leiden University, The Netherlands

1999-2003: PhD, Prof GJ Fleuren, Dr A. Gorter and Dr PJ Kuppen, dept. of Pathology, Leiden University: Eradication of tumor cells by the immune system by modulating membrane-bound complement regulatory proteins.
Certificates: Immunology (SMBWO) Experimental Pathobiology (SMBWO).

2004- Postdoc at Medical Inflammation Research: the role of Ncf1 in antigen presenting cells to regulate chronic inflammation

Publications

KA Gelderman, M Hultqvist, J Holmberg, P Olofsson, R Holmdahl
T cell surface redox levels determine T cell reactivity and arthritis susceptibility
Submitted

M Hultqvist, P Olofsson, KA Gelderman, J Holmberg, R Holmdahl
Oxidation therapy of arthritis
PloS Med, in press

KA Gelderman, A Gorter
Cross-linking tumor cells via CD55
MAI-platform Journal interview, in press

KA Gelderman, S Lam, CFM Sier, A Gorter
Immobilization of monocyte CD55 by bi-mAb opsonized tumor cells enhances CR3-dependent cellular cytotoxicity.
Eur J Immunol (2006); 36: 977-84

KA Gelderman, S Lam, A.Gorter
Inhibiting complement regulators in cancer immunotherapy with bispecific mAb
Expert Opin Biol Ther (2005); 5: 1593-601

KA Gelderman, PJK Kuppen, N Okada, GJ Fleuren, A Gorter
Tumor-specific inhibition of membrane-bound complement regulatory protein Crry with bispecific monoclonal antibodies prevents tumor outgrowth in a rat colorectal cancer lung metastases model
Cancer Res (2004); 64: 4366-72

KA Gelderman, S Tomlinson, GD Ross, A Gorter
Complement regulation on mAb-mediated immunotherapy of cancer
Trends Immunol (2004): 25; 158-164

CF Sier, KA Gelderman, FA Prins, A Gorter
Beta-glucan enhanced killing of renal cell carcinoma micro-metastases by monoclonal antibody G250 directed complement activation
Int J Cancer (2004): 109; 900-908

KA Gelderman, HJMAA Zijlmans, MJ Vonk, A Gorter
CD55 expression patterns on intestinal neuronal tissue are divergent from the brain.
Gut (2004): 53; 507-513

VT Blok, KA Gelderman, O Tijsma, MR Daha, A Gorter
Cytokines affect resistance of human tumor cells to complement mediated injury.
Scand J Immunol (2003): 57; 591-599

KA Gelderman, J Hakulinen, M Hagenaars, PJK Kuppen, S Meri, A Gorter
Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model.
Mol Immunol (2003): 40; 13-23

KA Gelderman, VT Blok, GJ Fleuren, A Gorter
The inhibitory effect of CD46, CD55 and CD59 on complement activation after immunotherapeutic treatment of cervical carcinoma cells with mAb or bispecific mAb.
Lab Invest (2003): 82; 483-493

KA Gelderman, PJK Kuppen, GJ Fleuren, W Bruin, A Gorter
Enhancement of the complement activating capacity of 17-1A mAb to overcome the effect of membrane-bound complement regulatory proteins on colorectal carcinoma.
Eur J Immunol (2002): 32; 128-135

"Pagetop"

Print version Tell a friend about this page