The Division of Molecular Medicine and Gene Therapy is located at the Biomedical Center (BMC), Lund University, Sweden. Established as a joint venture between the Medical Faculty at Lund University and the Hematology Clinic at Lund University Hospital, our mission is to translate basic science to clinical applications.
Our research focuses on hematopoiesis, the continuous and dynamic process of blood cell formation. The laboratory consists of eleven closely collaborating research groups that all share a common interest in investigating the properties of blood stem cells to eventually understand and treat hematological disorders.
Six of our researchers belong to the Hemato-Linné Excellence Linnaeus Research Environment funded by The Swedish Research Council and Lund University. Several of the groups are engaged in STEMTHERAPY, a Strategic Research Area for Stem Cells and Regenerative Medicine that is also supported by The Swedish Research Council.
Johan Flygare and Kenichi Miharada together with Leif Bülow from the Division of Pure and Applied Biochemistry are organising a cross-disciplinary conference on transfusion medicine in June 2015 in Lund. This conference will bring together world-leading scientists in an effort to discuss the latest research highlights from different research areas in the field of transfusion medicine.
Please welcome Linda Geironson Ulfsson to the Stem Cells and Leukemia group. Linda joined us from the Antigen Presentation group headed by Kajsa Paulsson at Lund University.
"The main purpose of my PhD project was to elucidate how the HLA class I dedicated chaperone, tapasin, mediates the quality control of HLA class I maturation in order to clarify which peptides are selected for presentation at the cell surface. A recombinant part of tapasin was shown to facilitate folding of different HLA class I allomorphs in a peptide- and allomorph-dependent manner. The aim of the project I will work on at the Molecular Medicine and Gene Therapy department is to identify and target leukemic stem cells in chronic myeloid leukaemia." Linda Geironson Ulfsson
The Swedish Society for Medical Research (SSMF) has awarded Sofie Singbrant Söderberg with their big grant for young researchers. The purpose is to allow young promising scientists to start up and establish their own independent research group. The aim of Sofie’s research is to discover novel strategies to increase red blood cell production to treat refractory anemia.
Congratulations to our new Ragnar Söderberg Fellows in Medicine 2014 Cristian Bellodi and Göran Karlsson! Cristian and Göran received 8 million SEK funding each for their work on post-transcriptional regulatory mechanisms that modulate stem cell function and the molecular mechanisms discriminating normal and malignant stem cells, respectively.
2014-10-01. Please welcome Visnja Radulovic to the Miharada group, who joined us from Gerald de Haans laboratory.
"The overall aim of my previous research was to better understand the role of two main epigenetic mechanisms, represented by the Polycomb-group proteins and DNA methyltransferases, in the regulation of hematopoietic stem cell (HSC) self-renewal and differentiation. The research project I will be working on at the Molecular Medicine and Gene Therapy department intends to describe the protein quality control and metabolic regulation of HSCs during the dormant-to-active state transition in order to generate improved protocols for ex vivo HSC expansion and transplantation." Visnja Radulovic