Molecular Medicine and Gene Therapy

Faculty of Medicine | Lund University

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Molecular Medicine and Gene Therapy

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The Division of Molecular Medicine and Gene Therapy is located at the Biomedical Center (BMC), Lund University, Sweden. Established as a joint venture between the Medical Faculty at Lund University and the Hematology Clinic at Lund University Hospital, our mission is to translate basic science to clinical applications.

Our research focuses on hematopoiesis, the continuous and dynamic process of blood cell formation. The laboratory consists of eight closely collaborating research groups that all share a common interest in investigating the properties of blood stem cells to eventually understand and treat hematological disorders.

Five of our researchers belong to the Hemato-Linné Excellence Linnaeus Research Environment funded by The Swedish Research Council and Lund University. Several of the groups are engaged in StemTherapy, a Strategic Research Area for Stem Cells and Regenerative Medicine that is also supported by The Swedish Research Council.

News

graphical abstract camp saxena
Graphical abstract. Stem Cell Reports DOI:10.1016/j.stemcr.2016.03.006

Congratulations to Shobhit Saxena and colleagues, whose paper "Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation" has been published in Stem Cell Reports. In this study, Shobhit Saxena, a former postdoc in the Woods group, could demonstrate a previously unrecognised role of cyclic AMP signaling in regulating human hematopoietic development.

- These findings advance the mechanistic understanding of hematopoietic development toward the development of transplantable human hematopoietic cells for therapeutic needs, says Niels-Bjarne Woods, last author of the study.

Congratulations to all authors!

Ulrika Blank Savukinas' artistic interpretation of Valgarður Sigurðsson et al's work made the cover of the latest issue of Cell Stem Cell. Congratulations!

- This is a great honor for us. Nowadays there are so many publications; ending up on the journal cover captures the reader’s interest for our work, says Kenichi Miharada, last author of the study.

  • Read the original article here.
cover cell stem cell
bcf 2016

The Swedish Childhood Cancer Foundation has taken decisions on applications in this year's open call for research positions within the area of childhood cancer diseases. Four position grants were awarded to researchers at the Divisions of Molecular Hematology and Molecular Medicine and Gene Therapy. We warmly congratulate Jenny Hansson on receiving a four-year position grant, and Mattias Aine, Valgardur Sigurdsson, and Ram Thakur on receiving a two-year postdoctoral fellowship each.

kristina munke

Please welcome Kristina Munke to the Singbrant Söderberg group. Kristina studies Biomedicine at Lund University and will be working on her bachelor thesis and a summer project in Sofie Singbrant Söderberg’s group.  

Welcome to our division Kristina!

From left: Jonas Larsson and Roman Galeev
Photo: Åsa Hansdotter

Using a genome-wide RNAi screen targeted to primary human hematopoietic stem and progenitor cells, Jonas Larsson and his team have identified several members of the cohesin complex as critical modifiers of renewal and differentiation. Their study was published in Cell Reports and strongly points toward a highly specific and dominant role of cohesin in regulating cell-fate decisions in hematopoietic stem cells.

Congratulations to the authors!

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