Stem Cell Center

Faculty of Medicine | Lund University

Mesenchymal Stem Cells and Cellular Therapies

Transplantation of hematopoietic stem cells is an effective therapy for a range of diagnoses, mostly patients with malignancies 

Today, mobilized peripheral blood stem cells (PBSC) that are harvested from the blood by standard apheresis techniques are used for transplantation. Our group is part of a major research consortium (CellCare) aiming to develop novel and improved stem cell collection and separation technology based on free flow acoustophoresis.

Furthermore, we develop translational cell therapies to provide the best possible transplants for the patients, especially for those undergoing allogeneic stem cell transplantation. State-of-the art ex-vivo manipulation techniques (selection/depletion/expansion) are utilized to improve hematopoietic engraftment, post-transplant immunological function and GvHD control.

Biology of (non-)hematopoietic stem and progenitor cells 

The cell therapy development is backed up by our preclincial research program on basic aspects of (stem) cell biology. Currently, one of the main projects focuses on the development and function of so-called marrow stromal cells (MSC). Using fluorescence-activated cell sorting and in-vivo mouse models we aim to identify the primary stromal stem cells and their distinct developmental stages.

Josefina Dykes
Josefina Dykes

Josefina Dykes gives a lecture in the Hematopoiesis seminar series. Title: Efficient removal of platelets from peripheral blood progenitor cell products using a novel micro-chip based acoustophoretic platform

Group Leader

Stefan Scheding
Stefan Scheding

Stefan Scheding
Dr. med., Associate Professor, Senior Consultant
tel: +46-46-222-3331/-3989
stefan.scheding@med.lu.se

News

2014-04-07 33 million SEK for faster medical diagnosis and improved stem cell therapies

2013-06-10 Stefan Scheding leads one of three main key projects funded by G Nilsson's Cancer Foundation.

2013-04-29 Stefan Scheding's group co-authors a new paper published in Cell Reports (Cell Press): "Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion"

2013-02-15 New paper on embryonic stem cell-derived MSC published by the Scheding group

2012-12-04 ACUSEP project - Integrated whole blood acoustophoresis and homogeneous nucleic acid detection cartridge for rapid sepsis diagnostics (ACUSEP)

2012-07-14 New website: Network for translational mesenchymal stem cell research (MSC-net)

MSC net

research program

Site overview