Lund center for Stem Cell Biology and Cell Therapy is one of six Swedish strategic centers of excellence in life sciences, supported by the Swedish Foundation for Strategic Research. Established in January 2003, the center focuses on stem cell and developmental biology of the central nervous and blood systems, and development of stem cell and cell replacement therapies in these organ systems as well as research in non-mammalian model systems.
Stefan Scheding leads one of three main key projects funded by G Nilsson's Cancer Foundation, The role of the (dys)regulated stem cell niche in normal hematopoiesis and clonal hematopoietic stem cell diseases - investigation of niche anatomy and function in normal and diseased human bone marrow.
Stefan Scheding's group co-authors a new paper published in Cell Reports (Cell Press): "Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion". This paper describes a promissing method to expand transplantable hematopoietic stem cells by co-culture with mesenchymal bone marrow stem cells grown as non-adherent mesenspheres.
The central nervous system’s mop-up crew, microglia, play an important role in protecting the brain against disease and injury. A research group at Lund University in Sweden has now developed a method that makes it possible to follow the behaviour of these support cells at close quarters. Increased knowledge about the specific role of microglia could open the door to new research avenues on several different neurological conditions, such as Parkinson’s disease and stroke.