The work of Karin Broberg follows three lines:
1. Health risks of metals: She investigates the importance of genetic variability for elimination and toxic effects of mercury, arsenic, lead and cadmium. Also, DNA damage and epigenetic effects of arsenic and cadmium are studied.
2. Health risks of low molecular weight agents: She investigates associations between exposure to low molecular weight agents, genetic variation in metabolic enzymes, gene expression patterns, metabolite levels and toxic effects among exposed workers.
3. Risk markers for cancer and cardiovascular disease: She characterises environmental and genetic factors influencing telomere length, a risk marker for cancer and cardiovacular disease.
There are competence, instruments and methods for genotyping including assessment of telomere length, gene expression analyses, analysis of DNA damage (8oxodG and Comet assay), DNA methylation. K Broberg leads the work-package: Gene-environment interactions within the EU Integrated Project PHIME (www.PHIME.org) and is responsible for the genetic analysis within the SIDA-financed project: Protective effects of prenatal micronutrient supplementation on arsenic induced immunosuppression in preschool children. Karin is PI for the projects: "Telomere length, exposure, chromosomal aberrations and cancer risk"; and "Exposure to diesel, metal particles, effects on the telomere length and the cardiovascular system – a follow-up study" both sponsored by the Swedish Council for Working life and Social research
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Department |
Environmental analytical chemistry |
Frågor om innehållet: Jenny Molested
Uppdaterad: 2011-09-16
