Experimental Epilepsy

Faculty of Medicine | Lund University


Merab Kokaia, Professor

Latest selected publications

Kokaia M, Andersson M, Ledri M
An optogenetic approach in epilepsy
Neuropharmacology. 2012 Jun 12.

Ledri M, Nikitidou L, Erdelyi F, Szabo G, Kirik D, Deisseroth K, Kokaia M
Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.
Eur J Neurosci. 2012 Apr 18.

Kokaia, M.
Seizure-induced neurogenesis in the adult brain.
Eur J Neurosci. 2011 Mar;33(6):1133-8. 

Kokaia M, Sørensen AT.
The treatment of neurological diseases under a new light: the importance of optogenetics.
Drugs Today (Barc). 2011 Jan;47(1):53-62.

Woldbye D, Angehagen M, Gøtzsche CR, Elbrønd-Bek H, Sørensen AT, Christiansen SH, Olesen MV, Nikitidou L, Hansen TO, Kanter-Schlifke I, Kokaia M
Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.
Brain . 2010 Aug 5.
Tønnesen J, Gonzalez Seiz E, Ramos M, Lindvall O, Martinez-Serrano A, Kokaia M
Functional properties of the human ventral mesencephalic neural stem cell line hVM1. 
Exp Neurol . 2010 Jan 29

Ledri M, Sørensen AT, Erdelyi F, Szabo G, Kokaia M.
Tuning afferent synapses of hippocampal interneurons by NPY. 
Hippocampus  2009 Dec 30

Tønnesen J, Sørensen AT, Deisseroth K, Lundberg C, Kokaia M
Optogenetic control of epileptiform activity 
PNAS  2009 Jul 21;106(29):12162-7.

Ahlenius H, Visan V, Kokaia M, Lindvall O, Kokaia Z.
Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. 
J Neurosci.  2009 Apr 8

Kanter-Schlifke I, Fjord-Larsen L, Kusk P, Angehagen M, Wahlberg L, Kokaia M.
GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus. 
Exp Neurol.  2009 Jan 7.

Sørensen AT, Nikitidou L, Ledri M, Lin EJ, During MJ, Kanter-Schlifke I, Kokaia M.
Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP.
Exp Neurol.  2008 Nov 10.

Jakubs K, Bonde S, Iosif RE, Ekdahl CT, Kokaia Z, Kokaia M, Lindvall O.
Inflammation Regulates Functional Integration of Neurons Born in Adult Brain. 
J Neurosci . 2008 Nov 19;28(47):12477-12488.

Sørensen AT, Kanter-Schlifke I, Lin EJ, During MJ, Kokaia M.
Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum. 
Mol Cell Neurosci . 2008 Oct;39(2):229-37.

Sørensen AT, Kanter-Schlifke I, Carli M, Balducci C, Noe F, During MJ, Vezzani A, Kokaia M
NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning. 
Hippocampus . 2008;18(6):564-74.

Parish CL, Castelo-Branco G, Rawal N, Tonnesen J, Sorensen AT, Salto C, Kokaia M, Lindvall O, Arenas E.
Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. 
J Clin Invest.  2008 Jan 2;118(1):149-160.

 Kanter-Schlifke I, Georgievska B, Kirik D, Kokaia M.
 Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy. 
  Mol Ther.  2007 Jun;15(6):1106-13.

 Jakubs K, Nanobashvili A, Bonde S, Ekdahl CT, Kokaia Z, Kokaia M*, Lindvall O*.
 Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. 
  Neuron . 2006 Dec 21;52(6):1047-59. * Equal contribution 

 Woldbye DP, Nanobashvili A, Sorensen AT, Husum H, Bolwig TG, Sorensen G, Ernfors P, Kokaia M.
 Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors. 
  Neurobiol Dis.  2005 Dec;20(3):760-72.

 Sorensen AT, Thompson L, Kirik D, Bjorklund A, Lindvall O, Kokaia M.
 Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts. 
  Eur J Neurosci.  2005 May;21(10):2793-9.

 Englund U, Bjorklund A, Wictorin K, Lindvall O, Kokaia M.
 Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. 
  PNAS . 2002 Dec 24;99(26):17089-94.

 Kokaia M, Holmberg K, Nanobashvili A, Xu ZQ, Kokaia Z, Lendahl U, Hilke S, Theodorsson E, Kahl U, Bartfai T, Lindvall O, Hokfelt T.
 Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin. 
  PNAS  2001 Nov 20;98(24):14006-11.

 Kokaia M.
 Long-term potentiation of single subicular neurons in mice. 
  Hippocampus . 2000;10(6):684-92.





 Telephone - +46462220547
 E-mail - Merab.Kokaia@med.lu.se 

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