Molecular Neuromodulation

Faculty of Medicine | Lund University

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Tomas Björklund, MSc, PhD | A/Prof

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Tomas Björklund, PhD

Group leader

Associate Professor of Neuroscience

Phone: +46 46 222 68 36

e-Mail: tomas.bjorklund@med.lu.se

Address:
Molecular Neuromodulation
Wallenberg Neuroscience Center

BMC, A10
22184, Lund
Sweden 


Earlier research work

I have over ten-year of experience in the fields of gene therapy, in vivo studies and Parkinson’s disease (PD). My earlier research work has focused on the development of novel AAV (adeno-associated viral) vector based therapies and disease models for PD and related disorders. Two major lines have emerged from that; an optimized therapy for PD using AAV mediated enzyme replacement and novel disease models for PD, Huntington’s disease and dementia with Lewy bodies. 
AAV-mediated enzyme replacement has become a very promising clinical candidate that is now being taken by my own company, Genepod Therapeutics, towards clinical trials in Parkinson patients. The disease models we have established using AAV-vectors have started to gain significant momentum and the results have been replicated in a number of labs.
We have recently completed two major studies utilizing a second generation, inhibitory chemogenetic receptor (commonly named DREADDs) in advanced in vivo experiments on cell transplantation for PD where we have for the first time been able to show important mechanisms underlying graft-induced abnormal involuntary movements or dyskinesias (published in Neuron).

Current research work

Translational combination of genome editing and chemogenetic modulation to dissect the striatal circuitry in vivo 
The main goal of this project is to validate our newly identified mechanism underlying the emergence of dyskinesias in PD and find a clinically applicable therapeutic approach to modulate this target. In our completed study (Neuron 2016), we have identified the 5-HT6 receptor as a potential therapeutic target in GIDs. In a follow-up study, we have furthered this approach and found mechanistic similarities between the GID and L-DOPA induced dyskinesias (LIDs). Recent studies point to the striatal cholinergic interneurons (AChINs) being a key player in the emergence and maintenance of LIDs in PD and that they can be inhibited through administration of muscarinic receptor antagonists. Using a novel ChAT-Cre transgenic rat in combination with the novel set of AAV-mediated orthogonal DREADDs, we have also shown that AChINs modulate LIDs in PD. In our ongoing work, we seek to bring all these data together and experimentally define a unified model of the Serotonin/Dopamine/Acetylcholine interaction in PD.

Barcode-based genetic screening of novel AAV serotypes for translational gene therapy
We have successfully developed a novel methodology to uniquely label each viral particle in a preparation with a unique identifier sequence (20 nucleotide random sequence) that is inserted in the 3’UTR (untranslated region) of mRNA expressed from the cell infected by that specific particle. Details on this process can be found in our Scientific reports 2016 paper. Using this approach, we have been able to develop an entirely new way to produce, screen and select new AAV serotypes that harbour infectivity profiles that are tailor-made for specific clinical applications.


Brief Curriculum Vitae

Employment

2016 – 2020 Assistant senior lecturer, a 4-year tenure track position, fully financed group leader position at the Medical Faculty, Lund University, 100% research time

2011 – Chief Operational Officer, COO of Genepod Therapeutics AB

Previous employments

2015 – 2016 Researcher (“Forskare”) and group leader at the Medical Faculty, Lund University. 

2011 – 2015 Assistant professor of Neuroscience and group leader at the Medical Faculty, Lund University. Fully funded position financed in competition from the Multipark SFO, 100% research time

2010 – 2011 Postdoctoral scientist at the Neuronal Plasticity and Repair unit,
 Medical Faculty, Lund University

2009 – 2010 Postdoctoral scientist at the B.R.A.I.N.S unit,
 Medical Faculty, Lund University

Higher education qualification

2016 Appointed as a Docent in Neuroscience at Lund University. 

2005 – 2009 PhD in Neuroscience at the Medical Faculty, Lund University (Dec 4, 2009)

2000 – 2005 Master of Medicine (Biomedicine) at the Medical Faculty, Lund University 

2003 – 2004 Biomedical Graduate School (Mathemathics and medicine) at Lund University 

2002 – 2003 Engineering mathematics, Lund Institute of Technology 

2000 Mathematics, Faculty of Science, Lund University

1999 Military service

Publication statistics

Total citations: 981, h-index: 17 (Google Scholar), 15 (Scopus and ISI web of knowledge where two papers are not listed), Mean IF: 8.2 (Max: 24.1, Min: 3.2), 8 “high impact” papers (IF >10), as of September 2016.

Intellectual property and entrepreneurship

Founding scientist and one of four board directors and Chief Operational Officer, COO of Genepod Therapeutics AB built around the invention listed below. 

Named Inventor of a two PCT, world-wide patent applications and one PRV patent application. The first so-far approved in 7 countries (40 pending). 

Appointments & Awards
 

2016 – External Expert reviewer for the Horizon 2020 Human Brain Project

2016 – External Expert reviewer for the National Science Centre, Poland

2013 – First prize in the Science Slam at the “Almedalen” political week, Gotland

2012 – Expert panelist for The French National Research Agency (ANR)

2012 First prize in a Science stand-up, “Kulturnatten”, Lund, Sweden

2011 – Expert panelist for the Research Council of Norway

2011 First prize in the Medicon Valley Alliance Science Slam

2011 Swedish Society for Medical Research. Two-year post doc fellowship

2007-2009 Board member of the Lund University Medical Faculty steering committee

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