The goal of our research is to develop vectors for use in gene therapy to treat diseases in the brain. Furthermore, we also aim to explore ways to modify CNS function by gene transfer.
In our lab we are constantly advancing the vector production and constructions to achieve as effective and specific lentivectors as possible.
One of our objectives is to develop cell-specific recombinant viral vectors to treat the hallmarks features of Parkinson’s disease (PD) such as dopaminergic cell death and L-DOPA induced dyskinesia. To achieve this goal we will use and further refine the cell-specific lentiviral vectors developed by our group during the last couple of years. Thus, we are constructing lentiviral vectors specific for PD by analyzing expression patterns in the PD striatum. We are combining our cell-specific technology with the possibility to down regulate proteins using RNA interference. In these projects we are not only developing tools to study the patophysiology of PD but also investigating possible new treatment paradigms for PD and proof-of-concepts that can be transferred to the study and treatment of other brain disorders.
Another objective for our research is to develop lentiviral vectors that can be regulated. This can be achieved either by giving inducing drugs or by utilizing the natural regulation of promoters in our vectors. These vectors will be improved for further use in the PD models.
We aim for our group environment to be challenging and creative as well as productive. Projects in our group aspire to be cutting edge and use state of the art technologies. We want our work environment to be open-minded, tolerant, respectful and collaborative…
... and last, but not the least, FUN!
The CNS Gene Therapy group participates in training of graduate and undergraduate students and provides state of the art research opportunities. As a member of our group you will have opportunity to improve your skills in analysis, leadership, project management, teaching and presenting.
Contact info:
Cecilia.Lundberg@med.lu.se
Tel: +46 46 222 05 28
2011-08-22. We welcome our new exchange student Giuseppe Manfre from University of Palermo! Giuseppe will stay with us until app. May 2012.
Page Manager: Paulina Pettersson
Last modified: 2011-08-22
Cecilia Lundberg, PhD
BMC A11
Lund University
SE-221 84 Lund, Sweden
Tel: + 46 46 222 05 28
Fax: + 46 46 222 05 59
e-mail: Cecilia.Lundberg@med.lu.se
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