Ole E. Sørensen leads one of the research groups at the Div. of Infection Medicine, Lund University. The research focus is innate immunity and particular the role of antimicrobial peptides in epidermis, seminal plasma, and neutrophils. For the research in the EGFR-mediated expression of antimicrobial peptides Ole E. Sørensen was awarded "Flormanska belöningen 2012" by the The Royal Swedish Academy of Sciences. The research was described in the November 2012 issue of
Current research projects include:
- The role of EGFR for regulation of the complement system
- Transcriptional regulation of EGFR-mediated gene expression
- Regulation of the expression and sorting of antimicrobial peptides in epidermis during wound healing
- Regulation of neutrophil function by epidermal proteins expressed during wound healing
- The molecular basis for the role of wound licking
- Enucleation in innate immunity
Professor Alexander M. Cole, University of Central Florida, USA, Professor Artur Schmidtchen, Lund University, Sweden, Professor Birthe B. Kragelund, University of Copenhagen, Denmark, Professor Jens-M. Schröder, Kiel University, Germany, Professor Niels Borregaard, Copenhagen University, Denmark, Professor Lars Björck, Lund University, Sweden, associate professor Matthias Mörgelin, Lund University, Sweden, Professor Peter Garred, University of Copenhagen, Denmark.
Generous funding to the research activities of the group has during the years been provided by:
Novo Nordisk Fonden
The Swedish Research Council
Alfred Österlunds stiftelse
Kgl. Fysiografiska Sällskapet, Lund
Greta och Johans Kocks stiftelser
Stiftelsen Clas Groshinskys Minnesfond
Alfred Benzon Fonden
Åke Wibergs stiftelse
Petrus och Augusta Hedlunds Stiftelse
Harald Jeanssons Stiftelse samt Harald och Greta Jeanssons stiftelse
Roupé, K. M., Nybo, M., Sjöbring, U., Alberius, P., Schmidtchen. A., Sørensen, O. E. (2010) Injury is the major inducer of epidermal innate immune responses during wound healing. J Invest Dermatol, 130, 1167–1177.
Edström Hägerwall , A. M. L.,Rydengård, V., Fernlund, P., Mörgelin, M., Baumgarten, M., Cole, A. M., Malmsten, M., Kragelund, B.B, Sørensen, O.E. (2012) β-microseminoprotein endows post coital seminal plasma with potent candidacidal activity by a calcium- and pH-dependent mechanism. PLoS Pathogens, 8, e1002625.
Abu-Humaidan AH, Ananthoju N, Mohanty T, Sonesson A, Alberius P, Schmidtchen A, Garred P, Sørensen O.E. (2014) The Epidermal Growth Factor Receptor Is a Regulator of Epidermal Complement Component Expression and Complement Activation. J Immunol. 192, 3355-64.
Mohanty, T., Sjögren, J., Kahn, F., Abu-Humaidan, A.H., Fisker, N., Assing, K., Mörgelin, M., Bengtsson, A.A., Borregaard, N., Sørensen, O. E. (2015) A Novel Mechanism for NETosis Provides Antimicrobial Defense at the Oral Mucosa. Blood - Prepublised on line as Blood First Edition paper, August 4, 2015)