Publications

P2 receptor publications

Reviews
Erlinge, D. Extracellular ATP: a growth factor for vascular smooth muscle cells, (Review). General Pharmacology (1998) 31, 1-8.

Erlinge, D. Vascular effects of extracellular nucleotides (Review). Kidney and Blood Pressure Research 24 382-385, 2001. (PDF)

Vascular Smooth Muscle - growth and differentiation
Erlinge, D., Yoo, H., Edvinsson, L., Reis, D.J. & Wahlestedt, C. Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters. Am. J. Physiol. (1993) 265, H1089-1097.

Erlinge, D., Brunkwall, J. & Edvinsson, L. Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP. Regulatory Peptides (1994) 50, 259-265.

Erlinge, D., You, J., Wahlestedt, C. & Edvinsson, L. Characterisation of an ATP receptor mediating mitogenesis in vascular smooth muscle cells. Eur. J. Pharmacol. Molecular Pharmacol. Sect. (1995) 289, 135-149.

Erlinge, D., Heilig, M. & Edvinsson, L. Tyrphostin inhibits ATP stimulation of DNA synthesis, cell proliferation and c-fos expression in vascular smooth muscle cells. Br. J. Pharmacol. (1996) 118, 1028-1034.

Erlinge, D., Hou, M., Webb, T.E., Barnard, E. & Möller, S. Phenotype changes of the vascular smooth muscle cell regulate P2 receptor expression as measured by quantitative RT-PCR. Biochem. Biophys. Res. Comm. (1998) 248, 864-870.

Hou, M., Möller, S., Edvinsson, L. and Erlinge, D. MAPKK-dependent growth factor induced upregulation of P2Y2-receptors in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. (1999) 258(3), 648-652. (PDF)

Hou, M., Möller, S., Edvinsson, L. and Erlinge, D. Cytokines induce upregulation of vascular P2Y2-receptors and increase mitogenic responses to UTP and ATP. Arteriosclerosis, Thrombosis and Vascular Biology 20 2064-2069, 2000.

Hou, M., Harden, TK., Kuhn, C., Baldetorp, B., Pendergast, W., Möller, S., Edvinsson, L. and Erlinge, D. UDP is a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors. American Journal of Physiology, Heart and Circulatory Physiology, 282 784-792, 2002. (PDF)

Wang L, Karlsson L, Moses S, Hultgårdh-Nilsson A, Andersson M, Borna C, Gudbjartsson T, Jern S. and Erlinge D. Specific P2 Receptor Expression in Human Vascular Smooth Muscle and Endothelial Cells.  J. Cardiovascular Pharmacology, 40(6), 841-853 2002.

Wang, L, Andersson, M, Karlsson, L, Watson, M-A, Cousens, D, Jern, S & Erlinge, D. Increase in mitogenic and decrease in contractile P2 receptors by fluid shear stress in intact human conduit vessels. Arteriosclerosis, Thrombosis and Vascular Biology, 2003. 23 1370-1376.

Platelets
Wang, L., Östberg, O, Wihlborg, A-K., Brogren, H, Jern, S & Erlinge, D. Quantification of ADP and ATP Receptor Expression in Human Platelets. J Thrombosis & Haemostasis, 1, 330-336, 2003.

Östberg Braun O, Jagroop A, Wang L, Mikhailidis D, Burnstock G, Erlinge D. Increased platelet purinergic sensitivity in peripheral arterial disease – a pilot study. Platelets 16 261-267, 2005.

Wang L, Erling P, Truedsson L, Bengtsson A, Sturfeld G and Erlinge D. Transcriptional Downregulation of Platelet ADP receptor in patients with Systemic Lupus Erythematosus. J Thrombosis & Haemostasis 2, 1436-42, 2004

Brogren H, Karlsson L, Andersson M, Wang L, Erlinge D & Jern S. Platelets synthesize large amount of active plasminogen activator-1. Blood  104 3943-3948, 2004.

Borna C, Lazarowski E,van Heusden C, Öhlin H & Erlinge, D. Resistance to aspirin is increased by ST-elevation myocardial infarction and correlates with adenosine diphosphate levels. Thrombosis Journal 26 10, 2005.

Endothelium
Malmsjö, M., Edvinsson, L. & Erlinge, D. P2U receptor-mediated endothelium-dependent but nitric oxide independent vascular relaxation. Br. J. Pharmacol. (1998) 123, 719-729. (PDF)

Malmsjö, M., Erlinge, D., Högestätt, E. & Zygmunt, P. Endothelial P2Y-receptors induce hyperpolarisation of vascular smooth muscle by release of endothelium-derived hyperpolarising factor. Eur. J. Pharmacol. (1999) 364, 169-173. (PDF)

Malmsjö, M., Edvinsson, L. and Erlinge, D. P2X1-receptors counteract the vasodilatory effects of endothelium derived hyperpolarising factor. European Journal of Pharmacology 364 169-173, 1999.(PDF)

Nilsson, T., Hrafnkelsdottir, T., Edvinsson, L., Jern, S., Erlinge, D. & Wall, U. Forearm blood flow responses to neuropeptide Y, noradrenaline and adenosine 5´-triphosphate in hypertensive and normotensive subjects. Blood Pressure 9 126-131, 2000.

Hrafnkelsdottir, T., Erlinge, D and Jern, S. Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man. Thrombosis & Haemostasis 85 875-881, 2001.(PDF)

Wihlborg, A-K, Malmsjö, M, Eyjolfsson, A, Gustafsson, A, Jacobson, K & Erlinge, D. Extracellular Nucleotides Mediate Vasodilation in Human Arteries via Prostaglandin, Nitric Oxide and Endothelium Dependent Hyperpolarising Factor (EDHF). Br J Pharmacol, 138,1451-1458, 2003.

Olivecrona G, Gothberg M, Wang L, Harnek J, Jacobson K, Erlinge D. Coronary artery reperfusion: The ADP receptor P2Y1 mediates early reactive hyperemia in vivo in pigs. Purinergic Signalling 1, 59-64, 2004.

Vascular contraction
Malmsjö, M., Bergdahl, A., Moller, S., Zhao, X-Y., Sun, X-Y., Hedner, T., Edvinsson, L. & Erlinge, D. Congestive heart failure induces down-regulation of P2X1-receptors in resistance arteries. Cardiovascular Research (1999) 43, 219-227. (PDF)

Zhao, X.H., Sun, X.Y., Erlinge, D., Edvinsson, L. & Hedner, T. Downregulation of adenosine and P2X receptor-mediated cardiovascular responses in heart failure rat. Blood Pressure 9 152-161, 2000.

Malmsjö, M., Hou, M., Harden, T.K., Pendergast, W., Pantev, E., Edvinsson, L. and Erlinge, D. Stable pyrimidine analogues discriminate between the P2Y-receptor subtypes mediating vasoconstriction of human coronary arteries. Journal of Pharmacology and Experimental Therapeutics 293 755-760 2000. (PDF)

Malmsjö, M., Adner, M., Harden, T.K., Pendergast, W., Edvinsson, L. and Erlinge, D. Stable pyrimidine analogues discriminate between the P2Y-receptor subtypes mediating vasoconstriction and vasodilatation of the rat mesenteric artery. British Journal of Pharmacology 131 51-56,2000.(PDF)

Borna, C., Wang, L., Gudbjartsson T., Karlsson, L., Jern, S. Malmsjö, M. & Erlinge, D. Contractile P2-receptors in human coronary bypass vessels. Annals of Thoracic Surgery, 76,50-57, 2003.

Wihlborg, A-K, Wang, L, Eyjolfsson, A, Gustafsson, A, Gubjartsson, T & Erlinge, D. Unmasking the vasoconstrictor response mediated by ADP receptor P2Y12 in human blood vessels. Arteriosclerosis, Thrombosis and Vascular Biology 24 1810-1815, 2004.

Heart
Hou, M., Malmsjö, M., Möller, S., Pantev, E., Bergdahl, A., Zhao, X-H., Sun, X-Y., Hedner, T., Edvinsson, L. and Erlinge, D. Increase in cardiac P2X1 and P2Y2-receptor mRNA levels in congestive heart failure. Life Sciences (1999) 65, 1195-1206.

Erlinge, D, Harnek, J, van Heusden, C, Olivecrona, G, Jern, S, & Lazarowski, E. Uridine triphosphate (UTP) is released during cardiac ischemia. International Journal of  Cardiology 100 427-433, 2005.

Balogh J, WihlborgAK, Isacksson H, Bhalchandra J, Jacobson KA, Arner A, Erlinge D. Phospholipase C and cAMP-dependent positive inotropic effects of ATP in mouse cardiac myocytes via P2Y11-like receptors. J Molecular and Cellular Cardiology 39 223-230, 2005.

Wihlborg AK, Balogh J, Wang L, Borna C, Bhalchandra J, Lazarowski E, Jacobson KA, Arner A, Erlinge D. Uridine nucleotides have positive inotropic effects in mouse cardiomyocytes with increased levels during myocardial infarction in man. Circulation Research 98, 970-976, 2006.

Pharmacology
Kim, H. S., Ravi, R. G., Marquez, V. E., Maddileti, S., Wihlborg, A-K., Erlinge, D., Malmsjo, M., Boyer, J. L., Harden, T. K. and Jacobson, K. A. Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring confirmation at P2Y1, P2Y2, P2Y4, and P2Y11, but not P2Y6 receptors. Journal of Medicinal Chemistry. 45 208-218, 2002. (PDF)

Wihlborg A-K, Slätt, J, Sun, X, Zhao, XH, Malmsjö, M, Bergman, J, Hedner, T & Erlinge, D. 2,2'-Nitrophenylisatogen Potentiates P2X1 Receptor Mediated Vascular Contraction and Blood Pressure Elevation. Drug Development Research, 2003, 59, 82-87.

Red blood cells
Wang L, Olivecrona G, Götberg M, Olsson ML, Sörhede Winzell M, Erlinge D. ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells. Circulation Research 96 189-196, 2005.

Swedish
Erlinge, D. Kardiovaskulär behandlingspotential: P2-receptorer viktiga för framtida läkemedel. Läkartidningen (1999) 21, 2586-2589), (Swedish)