Cardiology

Faculty of Medicine | Lund University

Department of Electrophysiology, Leipzig

The Department of Electrophysiology, Heart Center, University Leipzig (Germany) is one of the largest and busiest clinical, research and educational cardiac arrhythmia services in Europe. The main focus of our research group is to improve diagnosis and therapy of atrial fibrillation as well as sudden cardiac death. In particular, we are interested in the genetic contribution to cardiac arrhythmias, novel ECG and imaging methods for better arrhythmia diagnosis as well as interventional electrophysiology and device therapy.

Our department has two cardiac arrhythmia units with 50 beds, and in 2006 we have performed more than 1.400 invasive diagnostic procedures and ablations including 340 ablations for atrial fibrillation, and 1.200 pacemaker and defibrillator implants. Available facilities consist of two electrophysiology laboratories with state-of-the-art equipment for diagnostic and interventional cardiac electrophysiology, i.e. for electroanatomical mapping, image integration with pre-acquired 3-D CT, magnetic navigation as well as cardiac imaging with CT, MR and real-time 3-D echocardiography. We have established a platform for long-term cardiac rhythm monitoring with 7-day digital Holter ECGs, and implantable loop recorders as well as for home monitoring with implantable pacemakers and defibrillators.

Under Dr. Bollmann’s leadership, several novel ECG signal processing techniques have extensively been in applied in different research projects and clinical settings for optimizing atrial fibrillation management. The very close collaboration with the two teams in Lund (Profs. Olsson and Sörnmo) has formed the basis for initiation of this network proposal.

Project-related Personnel

Early-stage Researchers

Sebastian Hilbert, MD
Image integration for atrial fibrillation ablation

Sebastian Weiss, MD
Long-term ECG monitoring after atrial fibrillation AF ablation

Andreu Martinez Climent, MS
Preferential atrio-ventricular nodal conduction during atrial fibrillation (in cooperation with Polytechnic University Valencia, Spain)

Maria Guillem, MS
Non-invasive, high-density mapping of atrial fibrillation (in cooperation with Polytechnic University Valencia, Spain)

Valentina Corino, MS
Autonomic modulation of ventricular response during atrial fibrillation (in cooperation with Polytechnic University Milan, Italy)

Experienced Researchers

Andreas Bollmann, MD, FESC
Staff electrophysiologist
Head, In-patient Arrhythmia Unit

Daniela Husser, MD
Head, Cardiac Arrhythmia Research Center

Christopher Piorkowski, MD
Staff electrophysiologist
Head, Electrophysiology Laboratories

Arash Arya, MD
Staff electrophysiologist
Head, Pacemaker and Defibrillator Clinic

Gerhard Hindricks, MD
Head, Department of Electrophysiology

Other Collaborators

Project-related Publications

Husser D, Binias KH, Stridh M, Sornmo L, Olsson SB, Molling J, Geller C, Klein HU, Bollmann A. Non-invasive monitoring of oral flecainide’s effects on atrial electrophysiology during persistent human atrial fibrillation using the surface electrocardiogram. Ann Noninvasive Electrocardiol 2005; in press.

Husser D, Stridh M, Sörnmo L, Geller C, Klein HU, Olsson B, Bollmann A. Time-frequency analysis of the surface electrocardiogram for monitoring antiarrhythmic drug effects in atrial fibrillation. Am J Cardiol 2005;95:526-28.

Husser D, Bollmann A, Kang S, Stridh M, Sornmo L, Olsson SB, Bhandari AK, Cannom DS. Determinants and prognostic significance of immediate atrial fibrillation recurrence following cardioversion in patients undergoing pulmonary vein isolation. Pacing Clin Electrophysiol 2005; 28:119-25.

Husser D, Stridh M, Sornmo L, Platonov P, Olsson SB, Bollmann A. Analysis of the surface electrocardiogram for monitoring and predicting antiarrhythmic drug effects in atrial fibrillation. Cardiovasc Drugs Ther 2004; 18:377-86.

Bollmann A, Husser D, Olsson SB. Atrial fibrillatory frequency, atrial fibrillatory rate or atrial cycle length – does it matter? Am J Cardiol 2004; 94:147.

Husser D, Bollmann A, Kang S, Girsky MJ, Lerman RD, Cannom DS, Bhandari AK. Effectiveness of catheter ablation for coexisting atrial fibrillation and atrial flutter. Am J Cardiol 2004; 94:666-8.

Husser D, Stridh M, Sornmo L, Olsson SB, Bollmann A. Frequency analysis of atrial fibrillation from the surface electrocardiogram. Indian Pacing Electrophysiol J 2004; 4(3): 122-136.

Bollmann A, Husser D, Stridh M, Sörnmo L, Majic M, Klein HU, Olsson SB. Frequency measures obtained from the surface ECG in atrial fibrillation research and clinical-decision making. J Cardiovasc Electrophysiol 2003; 14,S154-S161.

Bollmann A, Husser D, Steinert R, Stridh M, Sörnmo L, Olsson SB, Polywka D, Molling J, Geller C, Klein HU. Echo- and electrocardiographic predictors for atrial fibrillation recurrence following cardioversion. J Cardiovasc Electrophysiol 2003; 14,S162-S165.

Bollmann A, Binias KH, Toepffer I, Molling J, Geller C, Klein HU. Importance of left atrial diameter and atrial fibrillatory frequency for conversion of persistent atrial fibrillation with oral flecainide. Am J Cardiol 2002; 90:1011-14.

Bollmann A, Mende M, Neugebauer A, Pfeiffer D. Atrial fibrillatory frequency predicts atrial defibrillation threshold and early arrhythmia recurrence in patients undergoing internal cardioversion of persistent atrial fibrillation. Pacing Clin Electrophysiol 2002; 25(8): 1179-84.

Bollmann A, Sonne K, Esperer HD, Toepffer I. Klein HU. Patients with persistent atrial fibrillation taking oral verapamil exhibit a lower atrial frequency on the ECG. Ann Noninvasive Electrocardiol 2002; 7:92-7.

Bollmann A, Binias KH, Grothues F, Schwerdtfeger A, Nikutta P, Klein HU. Left atrial appendage function and pulmonary venous flow in patients with nonrheumatic atrial fibrillation and their relation with spontaneous echo contrast. Echocardiography 2002; 19(1):37-43.

Bollmann A, Binias KH, Sonne K, Grothues F, Esperer HD, Nikutta P, Klein HU. Electrocardiographic characteristics in patients with nonrheumatic atrial fibrillation and their relation to echocardiographic parameters. Pacing Clin Electrophysiol 2001; 24:1507-13.

Bollmann A, Wodarz K, Esperer HD, Toepffer I, Klein HU. Response of atrial fibrillatory activity to carotid sinus massage in patients with atrial fibrillation. Pacing Clin Electrophysiol 2001; 24:1363-8.

Bollmann A. P-wave signal averaging in the management of patients with atrial fibrillation. Herzschr Elektrophys 2001; 12(2): 80-5.

Bollmann A, Binias K, Grothues F, Sonne K, Esperer H, Nikutta P, Klein H. Left atrial appendage flow in nonrheumatic atrial fibrillation : relationship with pulmonary venous flow and ECG fibrillatory wave amplitude. Chest 2001; 119:485-92.

Bollmann A, Sonne K, Esperer HD, Toepffer I, Klein HU. Circadian variations in atrial fibrillatory frequency in persistent human atrial fibrillation. Pacing Clin Electrophysiol 2000; 23:1867-71.

Bollmann A, Klein HU, Esperer HD. Determination of fibrillatory frequency for assessment of the atrial electrophysiologic state in human atrial fibrillation. Herzschr Elektrophys 2000; 11(2):77-87.

Bollmann A. Quantification of electrical remodeling in human atrial fibrillation. Cardiovasc Res 2000; 47:207-9.

Bollmann A, Sonne K, Esperer HD, Toepffer I, Langberg JJ, Klein HU. Non-invasive assessment of fibrillatory activity in patients with paroxysmal and persistent atrial fibrillation using the Holter ECG. Cardiovasc Res 1999; 44:60-6.

Bollmann A, Kanuru NK, McTeague KK, Walter PF, DeLurgio DB, Langberg JJ. Frequency analysis of human atrial fibrillation using the surface electrocardiogram and its response to ibutilide. Am J Cardiol 1998; 81:1439-45.

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