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Welcome to the Glycobiology Research Group

Katrin Mani  Assistant Professor tel: tel: +46 46 222 40 77 email:Katrin.Mani@med.lu.se

We are investigating the role of recycling glypican-1, a amyloid associated protein, in protein quality control in neurodegenerative diseases such as Alzheimer´s disease, prion disease, and Niemann pick type C disease. We demonstrate that glypican-1 functions as a chaperone by releasing its heparan sulfate side chains in endosomes where they react with oxidized misfolded proteins and target them for degradation. The knowledge reveal novel mechanisms for regulation of protein stability and result in the development of preventive and therapeutic strategies with significant impact in the field. A search for the mechanisms by which glypican-1 autoprocessing affect fibrillogenesis and neurodegeneration will enable us to design a new family of carbohydrate based drugs.

Key Words: Glypican, Heparan sulfate, Quality control, Prion, Scrapie, Amyloid, Alzheimer’s disease.