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Cellular and Molecular Pharmacology

Research in the Division focuses on a number of aspects and applications of molecular recognition for drug development, drug resistance, and clinical diagnosis and analysis.

Head of division is Fredrik Leeb-Lundberg. The division consists of four research groups:

• Biogenic amines - Lo Persson's research group 
• Biomedical polymer technology - Maria Kempe's research group 
• Drug Target Discovery - Fredrik Leeb-Lundberg's research group 

Current research areas include:

• Identification and analysis of epitopes necessary for hormone/drug-receptor and receptor-effector interactions.
• Construction of in vivo models to study novel drug targets in e.g. metabolic disease. .
• Development of synthetic entities with molecular recognition properties for analysis of clinical, environmental, and food samples and for the development of multifunctional nanodevices for targeted in vivo clinical diagnosis and therapeutic treatment.
• The use of combined structural and kinetic analyses of validated drug targets in the polyamine biosynthetic pathway for revealing high-resolution details of the drug target and its substrate/inhibitor interactions to be used in structure-based development of highly selective and specific drugs to combat proliferative disorders such as parasitic diseases and cancer.

Thus, the research represents a concerted effort to exploit molecular recognition patterns with the goal of developing tools to diagnose and treat multiple diseases.