Lund University Bioimaging Center

Faculty of Medicine | Lund University



Peer-reviewed scientific publications


Sjöholm K, Kilsgård O, Teleman J, Happonen L, Malmström L, Malmström J. Targeted proteomics and absolute protein quantification for the construction of a stoichiometric host-pathogen surface density model. Molecular & Cellular Proteomics. February 9, 2017. M116.063966.


Hansen JS, Krintel C, Hernebring M, Haataja TJK, de Marèa S, Wasserstrom S, Kosinska-Eriksson U, Palmgren M, Holm C, Stenkula KG.
Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation.
Metabolism. Volume 65, Issue 12, December 2016, Pages 1731–1742.

Lampinen B, Szczepankiewicz F, Mårtensson J, Van Westen D, Sundgren P C, Nilsson M.
Neurite Density Imaging Versus Imaging of Microscopic Anisotropy in Diffusion MRI: A Model Comparison Using Spherical Tensor Encoding.
Neuroimage. 2016 Nov 27;147:517-531.

Dublon, I, Nilsson M, Balkenius A, Anderson P, Larsson MC.
Scintillate; an open-source graphical viewer for time-series calcium imaging evaluation and pre-processing.
Journal of Neuroscience Methods, 2016 Nov 1;273:120-127

Santillo A, Lundblad K, Nilsson M, Landqvist Waldö M, van Westen D, Lätt J, Nordström Blennow E, Vesterberg S, Lindberg O, Nilsson C.
Grey and White Matter Clinico-Anatomical Correlates of Disinhibition in Neurodegenerative Disease.
PLoS ONE 11(10): e0164122.

Olsson P O, Gustafsson R, in ’t Zandt R, Friman T, Maccarana M, Tykesson E, Oldberg Å, Rubin K, Kalamajski S.
The tyrosine kinase inhibitor Imatinib augments extracellular fluid exchange and reduces average collagen fibril diameter in experimental carcinoma.
Mol Canc Therapeut, accepted.

Degerman E, in ’t Zandt R, Pålbrink A, Eliasson L, Caye-Thomasen P, Magnusson M.
Inhibition of Phosphodiesterase 3, 4 and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.
Acta Oto-Laryngologica, accepted

Evertsson M, Kjellman P, Cinthio M, Andersson R, Tran T A, in ’t Zandt R, Grafström G, Toftevall H, Fredriksson S, Ingvar C, Strand S-E, Jansson T.
In vivo detection of 68Ga-labelled superparamagnetic iron oxide nanoparticles in rat sentinel lymph nodes using PET/CT, Magnetomotive ultrasound and MRI.
American Journal of Nuclear Medicine and Molecular Imaging (AJNMMI), accepted.

Surova Y, Lampinen B, Nilsson M, Lätt J, Hall S, Widner H, the Swedish BioFINDER study, van Westen D, Hansson O.
Alterations of diffusion kurtosis and neurite density indexes in deep grey matter and white matter in Parkinson’s disease.
PLoS ONE 11(6): e0157755.

Falk Delgado A, Nilsson M, Latini L, Mårtensson J, Zetterling M, Ghaderi Berntsson S, Alafuzoff I, Lätt J, Larsson E-M.
Preoperative semi-quantitative MR tractography compared with visual tract evaluation and neuropathological diagnosis in patients with suspected low-grade glioma: A prospective cohort study.
Radiology Research and Practice, 2016.

Lampinen B, Szczepankiewicz F, van Westen D, Englund E, Sundgren P, Lätt J, Ståhlberg F, Nilsson M.
Optimal Experimental Design for Filter Exchange Imaging: Apparent Exchange Rate Measurements in the Healthy Brain and in Intracranial Tumors.
Magnetic Resonance in Medicine, 2016.

Ahlgren A, Knutsson L, Wirestam R, Nilsson M, Ståhlberg F, Topgaard D, Lasič S.
Quantification of microcirculatory parameters by joint analysis of flow-compensated and non-flow-compensated intravoxel incoherent motion (IVIM) data.
NMR Biomed. 2016 29(5):640-9.

Vilhelmsson Timmermand O, Larsson E, Ulmert D, Tran TA, Strand SE
Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2
EJNMMI Res. 2016; 6: 27. Published online 2016 March 17. doi:  10.1186/s13550-016-0181-z

Westin CF, Knutsson H, Pasternak O, Szczepankiewicz F, Özarslan E, van Westen D, Mattisson C, Bogren M, O'Donnell L, Kubicki M, Topgaard D, Nilsson M.
q-space trajectory imaging for multidimensional diffusion MRI of the human brain.
Neuroimage. 2016 Feb 23. pii: S1053-8119(16)00148-8.

Pehrson C, Mathiesen L, Heno KK, Salanti A, Resende M, Dzikowski R, Damm P, Hansson SR, King CL, Schneider H, Wang CW, Lavstsen T, Theander TG, Knudsen LE, Nielsen MA
Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria.
Malaria Journal 2016 15:292 DOI: 10.1186/s12936-016-1342-2, Published: 26 May 2016.

Lasič S, Oredsson S, Partridge SC, Saal LH, Topgaard D, Nilsson M, Bryskhe K.
Apparent exchange rate for breast cancer characterization.
NMR Biomed. 2016 May;29(5):631-9.

Follin C, Gabery S, Petersén Å, Sundgren PC, Björkman-Burtcher I, Lätt J, Mannfolk, Erfurth EM.
Associations between Metabolic Risk Factors and the Hypothalamic Volume in Childhood Leukemia Survivors Treated with Cranial Radiotherapy.
PLoS One. 2016 Jan 29;11(1):e0147575.

Cuellar-Baena S, Landeck N, Sonnay S, Buck K, Mlynarik V, Zandt RI, Kirik D.
Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo1 H-MR spectroscopy at 9.4 T.
J Neurochem. 2016 Jan 26. [Epub ahead of print]


Sjölund J, Szczepankiewicz F, Nilsson M, Topgaard D, Westin CF, Knutsson H.
Constrained optimization of gradient waveforms for generalized diffusion encoding.
J Magn Reson. 2015 261:157-68.

Nilsson M, Szczepankiewicz F, van Westen D, Hansson O.
Extrapolation-Based References Improve Motion and Eddy-Current Correction of High B-Value DWI Data: Application in Parkinson’s Disease Dementia.
PLoS One. 2015 Nov 3;10(10):e0141825. [Epub ahead of print]

Kjellman P, Fredriksson S, Kjellman C, Sven-Erik Strand S-E, in ‘t Zandt R.
Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases.
Future Science OA. 2015. [Epub ahead of print]

Ahlstedt J, Tran TA, Strand F, Holmqvist B, Strand S-E, Gram M, Åkerström B.
Biodistribution and pharmacokinetics of recombinant α1-microglobulin and its potential use in radioprotection of kidneys.
Am J Nucl Med Mol Imaging 2015;5(4):333-347, /ISSN:2160-8407/ajnmmi0007393. Published July 1, 2015.

Degerman E, In 't Zandt R, Pålbrink A, Magnusson M.
Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI.
Hear Res. 2015 Jun 3. pii: S0378-5955(15)00116-1. [Epub ahead of print]

Manouchehrian O, Arnér K, Deierborg T, Taylor L.
Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration.
J Neuroinflammation. 2015 12:92.

Bosemark P, Perdikouri C, Pelkonen M, Isaksson H, Tägil M.
The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect.
J Orthop Res. 2015 Apr;33(4):488-95.

Eriksson S, Lasič S, Nilsson M, Westin C-F, Topgaard D.
NMR diffusion-encoding with axial symmetry and variable anisotropy: Distinguishing between prolate and oblate microscopic diffusion tensors with unknown orientation distribution.
J. Chem. Phys. 142, 104201 (2015). [Epub ahead of print]

Timmermand OV, Tran TA, Strand SE, Axelsson J.
Intratherapeutic biokinetic measurements, dosimetry parameter estimates, and monitoring of treatment efficacy using cerenkov luminescence imaging in preclinical radionuclide therapy.
J Nucl Med. 2015 Mar;56(3):444-9. Epub 2015 Feb 5.

Vilhelmsson-Timmermand O, Santos E, Thorek D.L.J., Evans-Axelsson S, Bjartell A, Lilja H, Larson S.M., Strand S-Ea, Tran T.A., Ulmert D.
Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.
Nuclear Medicine and Biology. In press. [Epub ahead of print]


Vilhelmsson Timmermand O, Ulmert D, Evans-Axelsson S, Pettersson K, Bjartell A, Lilja H, Strand SE and Tran TA.
Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6.
EJNMMI Research 2014, 4:51 [Epub ahead of print]

Filip Szczepankiewicz F, Lasič S, van Westen D, Sundgren P C, Englund E, Westin C-F, Ståhlberg F, Lätt J, Topgaard D and Nilsson M.
Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: Applications in healthy volunteers and in brain tumors.
Neuroimage. 2014 Oct 2. pii: S1053-8119(14)00799-X. [Epub ahead of print]

Siikanen J, Tran T A, Olsson T G, Strand S-E, Sandell A.
A solid target system with remote handling of irradiated targets for PET cyclotrons.
Appl Radiat Isot. 2014 Sep 16;94C:294-301. [Epub ahead of print]

Braekeveldt N, Wigerup C, Gisselsson D, Mohlin S, Merselius M, Beckman S, Jonson T, Börjesson A, Backman T, Tadeo I, Berbegall AP, Ora I, Navarro S, Noguera R, Påhlman S, Bexell D.
Neuroblastoma Patient-Derived Orthotopic Xenografts Retain Metastatic Patterns and Geno- and Phenotypes of Patient Tumours.
Int J Cancer. 2014 Sep 15. [Epub ahead of print]

Rydhög AS, van Osch MJ, Lindgren E, Nilsson M, Lätt J, Ståhlberg F, Wirestam R, Knutsson L.
Intravoxel incoherent motion (IVIM) imaging at different magnetic field strengths: What is feasible?
Magn Reson Imaging. 2014 Aug 11. [Epub ahead of print]

Evertsson M, Kjellman P, Cinthio M, Fredriksson S, In 't Zandt R, Persson H, Jansson T.
Multimodal detection of iron oxide nanoparticles in rat lymph nodes using magnetomotive ultrasound imaging and magnetic resonance imaging.
IEEE Trans Ultrason Ferroelectr Freq Control. 2014 Aug;61(8):1276-83.

Evans-Axelsson S, Vilhelmsson Timmermand O, Welinder C, Borrebaeck CA, Strand SE, Tran TA, Jansson B, Bjartell A.
Preclinical evaluation of (111)In-DTPA-INCA-X anti-Ku70/Ku80 monoclonal antibody in prostate cancer.
Am J Nucl Med Mol Imaging. 2014 Jun 7;4(4):311-23.

Madru R, Svenmarker P, Ingvar C, Ståhlberg F, Andersson Engels S, Knutsson L,  Strand S-E.
Development of a Hybrid Nanoprobe for Triple-Modality MR/SPECT/Optical Fluorescence Imaging.
Diagnostics 2014, 4(1), 13-26.

Lasič S, Szczepankiewicz F, Eriksson S, Nilsson M, Topgaard D.
Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector.
Front. Physics 2:11 2014. doi: 10.3389/fphy.2014.00011 [Epub ahead of print]

Kjellman P, in ‘t Zandt R, Fredriksson S, Strand S-E.
Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring.
Nanomedicine. 2014 Feb 3. pii: S1549-9634(14)00031-8. [Epub ahead of print]


Mårtensson J, Nilsson M, Ståhlberg F, Sundgren PC, Nilsson C, van Westen D, Larsson EM, Lätt J.
Spatial analysis of diffusion tensor tractography statistics along the inferior fronto-occipital fasciculus with application in progressive supranuclear palsy.
MAGMA. 2013 Dec;26(6):527-37

Madru R1, Tran TA2, Axelsson J3, Ingvar C4, Bibic A1, Ståhlberg F5, Knutsson L1, Strand SE2.
(68)Ga-labeled superparamagnetic iron oxide nanoparticles (SPIONs) for multi-modality PET/MR/Cherenkov luminescence imaging of sentinel lymph nodes.
Am J Nucl Med Mol Imaging. 2013 Dec 15;4(1):60-9.

Frizell Santillo A, Mårtensson J, Lindberg O, Nilsson M, Manzouri A, Landqvist Waldö M, van Westen D, Wahlund L-O, Lätt J, Nilsson C.
Diffusion Tensor Tractography versus Volumetric Imaging in the Diagnosis of Behavioral Variant Frontotemporal Dementia.
PLoS One. 2013 Jul 18;8(7):e66932.

Östner G, Lindström V, Hjort Christensen P, Kozak M, Abrahamson M, Grubb A.
Stabilization, characterization, and selective removal of cystatin C amyloid oligomers.
J Biol Chem 288:16438-50.

Surova Y, Szczepankiewicz F, Lätt J, Nilsson M, Eriksson B, Leemans A, Hansson O, van Westen D, Nilsson C.
Assessment of Global and Regional Diffusion Changes along White Matter Tracts in Parkinsonian Disorders by MR Tractography.
PLoS One. 2013 Jun 13;8(6):e66022.

Markus Nilsson M, van Westen D, Ståhlberg F, Sundgren P C and Lätt J.
The role of tissue microstructure and water exchange in biophysical modelling of diffusion in white matter.
Magnetic Resonance Materials in Physics, Biology and Medicine, 2013 vol. 26, issue 4, 345-370.

Szczepankiewicz F, Lätt J, Wirestam R, Leemans A, Sundgren P, van Westen D, Ståhlberg F, Nilsson M.
Variability in diffusion kurtosis imaging: impact on study design, statistical power and interpretation.Neuroimage.
2013 Aug 1;76:145-54.

Nikitidou, L.
Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin.

Hall H, Cuellar-Baena S, Denisov V, Kirik D.
Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue.
J Neurochem. 2013 Feb;124(3):336-46.


Tolmachev V, Tran T A, Rosik D, Sjöberg A, Abrahmsén L, Orlova A.
Tumor Targeting Using Affibody Molecules: Interplay of Affinity, Target Expression Level, and Binding Site Composition.
The Journal Of Nuclear Medicine, 2012 vol. 53 no. 6.

Evans-Axelsson S, Ulmert D, Örbom A, Paterson P, Nilsson O, Wennerberg J, Strand J, Wingårdh K, Olsson T, Hagman Z, Tolmachev V, Bjartell A, Lilja H, Strand S-E.
Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone.
Cancer Biother Radiopharm. 2012 May;27(4):243-51.

Madru R, Kjellman P, Olsson F, Wingårdh K, Ingvar C, Ståhlberg F, Olsrud J, Lätt J, Fredriksson S, Knutsson L, Strand SE.
99mTc-Labeled Superparamagnetic Iron Oxide Nanoparticles for Multimodality SPECT/MRI of Sentinel Lymph Nodes.
J Nucl Med March 1, 2012 vol. 53 no. 3 459-46.

Siikanen J, Peterson M, Tran T A, Roos P, Ohlsson T, Sandell A.
A peristaltic pump driven 89Zr separation module.
AIP Conf. Proc. 1509, 206.

Moser E, Stahlberg F, Ladd ME, Trattnig S.
7-T MR-from research to clinical applications?
NMR Biomed. Vol. 25 no. 5 695-716.


Hansson MJ, Morota S, Chen L, Matsuyama N, Suzuki Y, Nakajima S, Tanoue T, Omi A, Shibasaki F, Shimazu M, Ikeda Y, Uchino H, Elmér E.
Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.
J Neurotrauma, 2011 Jan;28(1):143-153.

Tran T A, Kirik D.
Imaging of Brain Prion Protein amyloid in Patients with Gertstmann-Sträussler-Scheinker Disease.
Zdravniški vestnik / Slovenian Medical Journal, 2011 vol. 80 no. 12, 969 - 970

Qvarnström OF, Simonsson M, Carlsson J, Tran TA.
Effects of affinity on binding of HER2-targeting Affibody molecules: model experiments in breast cancer spheroids.
Int J Oncol. 2011 Aug;39(2):353-9.

Siikanen J, Ohlsson T, Sandell A, Strand SE, Tran TA.
Labeling proteins with 89Zr separated from large yttrium bulks.
J Nucl Med. 2011; 52 (Supplement 1):1504


Cudalbu C, Comment A, Kurdzesau F, van Heeswijk RB, Uffmann K, Jannin S, Denisov V, Kirik D, Gruetter R.
Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats. 
Phys Chem Chem Phys. 2010 Jun 14;12(22):5818-23.

Axelsson J, Rippe A, Rippe B.
Acute hyperglycemia induces rapid, reversible increases in glomerular permeability in nondiabetic rats.
Am J Physiol Renal Physiol 289: F1306-F1312.


Sarkar R, Comment A, Vasos PR, Jannin S, Gruetter R, Bodenhausen G, Hall H, Kirik D, Denisov VP.
Proton NMR of (15)N-choline metabolites enhanced by dynamic nuclear polarization.
J Am Chem Soc. 2009 Nov 11;131(44):16014-5.

Book chapters


Westin C-F, Szczepankiewicz F, Pasternak O, Özarslan E, Topgaard D, Knutsson H, and Nilsson M.
Measurement Tensors in Diffusion MRI: Generalizing the Concept of Diffusion Encoding.
Med Image Comput Comput Assist Interv. 2014;17(Pt 3):209-16.

Hall H, Cuellar-Baena S, Dahlberg C, In't Zandt R, Denisov V, Kirik D.
Magnetic Resonance Spectroscopic Methods for the Assessment of Metabolic Functions in the Diseased Brain.
Curr Top Behav Neurosci. 2012;11:169-98.

PhD and Licenciate Theses


Evertsson, Maria
Development of Magnetomotive Ultrasound Imaging
Department of Biomedical Engineering, Faculty of Engineering LTH, Lund University


Kjellman, Pontus
Multimodal sentinel lymph node imaging using nanoscale-tailored particles; The importance of particle size
Department of Medical Radiation Physics, Faculty of Medicine, Lund University.


Bosemark, Per
Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
Department of Orthopaedics, Lund University

Vilhelmsson Timmermand, O.
Radioimmunoimaging and Radioimmunotherapy of Prostate Cancer Preclinical evaluation of kallikrein related peptidase 2 targeting.
Department of Medical Radiation Physics, Faculty of Medicine, Lund University.

Isaksson, K.
Small bowel obstruction and toxicity of a new model of adhesion prevention.
Department of Clinical Sciences, Faculty of Medicine, Lund University.


Evans Axelsson, S.
Preclinical imaging of prostate cancer using radiolabeled antibodies.
Division of Urological Cancers, Faculty of Medicine, Lund University.

Örbom, A.
Preclinical Molecular Imaging using Multi-Isotope Digital Autoradiography – Techniques and Applications.Medical Radiation Physics, Science Faculty, Lund University.

Nikitidou L.
Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin.Neurology, Faculty of Medicine, Lund University.

Békássy, Z.
Studies of EHEC and the complement system in renal diseases.
Department of Pediatrics, Faculty of Medicine, Lund University.

Bibic A.
Noise reduction and modeling in quantitative MRI: Application to perfusion and diffusion imaging.
Department of Medical Radiation Physics, Lund University, Licenciate dissertation.


Axelsson J.
Dynamics of the glomerular filtration barrier.Physiological and pathological aspects.
Department of Nephrology, Faculty of Medicine, Lund University.


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