Parkinson’s disease and Huntington’s disease are caused by the death of nerve cells in the part of the brain called basal ganglia.
Our goal is to develop and improve treatments for the diseases and to improve quality of life for patients and their families.
The majority of our brain cells are formed in the embryonic stage. However, there are a few structures in the brain where new neurons continue to form throughout adulthood. A BAGADILICO research group has studied such a population of neurons and discovered that they can be guided towards building more advanced paths of communication with their surrounding environment. An increased understanding of the function of newborn brain cells could eventually explain the underlying causes of various diseases of the brain and open up for new treatments.
Normally, a thesis flies well below the radar of the broader scientific community. This one doesn’t. Each of the key findings in Olof Torper’s thesis has raised eyebrows among researchers worldwide. The concept of direct conversion is one that translates well into layman’s terms and as a result the science presented has also caught the media’s attention.
A new study from BAGADILICO researchers, in collaboration with Nobel Prize winner Paul Greengard, presents an exhaustive mapping of the circuits that are involved in the development dyskinesia in Parkinson's disease. The involuntary movements are the main drawback of the one major pharmacotherapy for Parkinson's existing today, L-Dopa.